CMV-Specific T Cells Generated from Naïve T Cells Recognize Atypical Epitopes and May Be Protective In Vivo Investigators demonstrated the feasibility of deriving cytomegalovirus (CMV)-specific T cells from naïve cells for T cell therapy. Naïve T cells primed to recognize CMV were restricted to different, atypical epitopes than T cells derived from CMV-seropositive individuals; however, these two cell populations had similar avidities. [Sci Transl Med] Abstract | Press Release Ipilimumab-Dependent Cell-Mediated Cytotoxicity of Regulatory T Cells Ex Vivo by Nonclassical Monocytes in Melanoma Patients Researchers studied 29 patients with advanced cutaneous melanoma treated with ipilimumab. They analyzed peripheral blood mononuclear cells and matched melanoma metastases from 15 patients responding and 14 not responding to ipilimumab by multicolor flow cytometry, antibody-dependent cell-mediated cytotoxicity assay, and immunohistochemistry [Proc Natl Acad Sci USA] Abstract Myeloid Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy The numbers of granulocytic and monocytic MDSC subsets, effector T cells and regulatory T cells in the peripheral blood were evaluated pre- and post-sunitinib treatment and concurrent with stereotactic body radiotherapy. [Clin Cancer Res] Abstract Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy Researchers characterized GM-CSF production by T cells of multiple sclerosis (MS) patients and determined the effect of IFN-β therapy on its production. GM-CSF production by peripheral blood T cells and the effects of IFN-β were characterized in samples of untreated and IFN-β–treated MS patients versus healthy subjects. [J Immunol] Abstract | Press Release Intratumoral Injection of IFN-Alpha Dendritic Cells after Dacarbazine Activates Anti-Tumor Immunity: Results from a Phase I Trial in Advanced Melanoma Scientists tested in a Phase I clinical study in advanced melanoma a chemo-immunotherapy approach based on unloaded dendritic cells generated in presence of interferon-alpha (IFN-alpha) injected intratumorally one day after administration of dacarbazine. [J Transl Med] Abstract | Full Article Cytotoxicity and Infiltration of Human NK Cells in In Vivo-Like Tumor Spheroids Three-dimensional in vivo-like tumor spheroids were established from human cervical carcinoma cell lines as proof of concept to investigate infiltration and cytotoxicity of NK cells in a 96-well plate format. Tumor spheroids were monitored for NK cell infiltration and cytotoxicity by flow cytometry. [BMC Cancer] Abstract | Full Article The Receptor for Advanced Glycation End Products (RAGE) Enhances Autophagy and Neutrophil Extracellular Traps in Pancreatic Cancer Neutrophil extracellular traps (NETs) have an important role in the pathogenesis of several sterile inflammatory diseases, including malignancy, therefore researchers investigated the role of NETs in the setting of pancreatic ductal adenocarcinoma. [Cancer Gene Ther] Abstract Serum Level of Soluble Interleukin-2 Receptor Correlates with CD25 Expression in Patients with T Lymphoblastic Lymphoma The authors examined the serum level of soluble interleukin-2 receptor in 23 patients with T lymphoblastic lymphoma and compared these with the levels in 20 patients with T acute lymphoblastic leukemia, 40 patients with diffuse large B-cell lymphoma and 40 patients with peripheral T-cell lymphoma, not otherwise specified. [J Clin Pathol] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |