Cord Blood Monocyte–Derived Inflammatory Cytokines Suppress IL-2 and Induce Nonclassic “TH2-Type” Immunity Associated with Development of Food Allergy Scientists found that in infants who developed food allergy, cord blood displayed a higher monocyte to CD4+ T cell ratio and a lower proportion of natural regulatory T cell in relation to duration of labor. [Sci Transl Med] Abstract | Press Release Inhibition of Diacylglycerol Kinase α Restores Restimulation-Induced Cell Death and Reduces Immunopathology in XLP-1 Researchers showed that down-regulation of diacylglycerol kinase α activity in signaling lymphocytic activation molecule–associated protein-deficient T cells restores diacylglycerol signaling at the immune synapse and rescues restimulation-induced cell death via induction of the proapoptotic proteins NUR77 and NOR1. [Sci Transl Med] Abstract | Press Release Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines Scientists showed that IL-36α, IL-36β, and IL-36γ are activated differentially by the neutrophil granule-derived proteases cathepsin G, elastase, and proteinase-3, increasing their biological activity ~500-fold. [Cell Rep] Full Article | Graphical Abstract | Press Release Cytotoxic Polyfunctionality Maturation of Cytomegalovirus-pp65-Specific CD4+and CD8+ T-Cell Responses in Older Adults Positively Correlates with Response Size Researchers examined the in vitro cytomegalovirus-pp65-reactive T-cell response by comprehensively studying five effector functions (i.e., interleukin-2, tumor necrosis factor-α, interferon-γ, perforin, and CD107a expression) in 76 seropositive individuals aged 70 years or older. [Sci Rep] Full Article Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System Researchers examined the frequency and phenotype of monocyte subpopulations in peripheral blood, cerebrospinal fluid, and brain biopsy material derived from multiple sclerosis patients and controls. [J Immunol] Abstract IL-6 Down-Regulates HLA Class II Expression and IL-12 Production of Human Dendritic Cells to Impair Activation of Antigen-Specific CD4+ T Cells The authors focused on the role of interleukin (IL)-6/signal transducer and activator of transcription signaling cascade in immune regulation by human dendritic cells (DCs). IL-6-conditioned monocyte-derived DCs impaired the presenting ability of cancer-related antigens. [Cancer Immunol Immunother] Abstract The CII-Specific Autoimmune T-Cell Response Develops in the Presence of FTY720 but Is Regulated by Enhanced Treg Cells that Inhibit the Development of Autoimmune Arthritis Scientists analyzed the effect of fingolimod (FTY720) on the autoimmune T- and B-cell response in autoimmune arthritis and studied the mechanisms by which it alters the function of T cells. [Arthritis Res Ther] Full Article The Multiple Sclerosis Susceptibility Genes TAGAP and IL2RA Are Regulated by Vitamin D in CD4+ T Cells In CD4+ T cells, investigators analyzed in vitro vitamin D responsiveness of genes that contain a multiple sclerosis-associated single-nucleotide polymorphism and with one or more vitamin D response elements in their regulatory regions. They identified IL2RA and TAGAP as novel vitamin D target genes. [Genes Immun] Full Article Human Regulatory T Cells Suppress Proliferation of B Lymphoma Cells Allogeneic polyclonal CD4+CD25+ regulatory T cells (Tregs) and CD4+CD2+CD127lo Tregs expanded in vitro in the presence of rapamycin and low dose IL-2 suppressed proliferation of 11 out of 12 established lymphoma B‑cell lines. [Leuk Lymphoma] Abstract Differentiation of Human Monocytes and Derived Subsets of Macrophages and Dendritic Cells by the HLDA10 Monoclonal Antibody Panel Blood monocytes critically contribute to tissue macrophage and dendritic cell (DC) pools upon inflammation. To better understand the relationship between these populations and their phenotype, investigators isolated and differentiated human blood CD14+ monocytes in vitro into immature and mature monocyte-derived dendritic cells as well as into seven different monocyte-derived macrophage subsets. [Clin Transl Immunol] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |