Regional Specialization of T Cell Subsets and Apoptosis in the Human Gut Mucosa: Differences between Ileum and Colon in Healthy Intestine and Inflammatory Bowel Diseases Scientists determined differences in immune compartmentalization between ileum and colon in healthy and inflamed mucosa. Healthy colon showed higher percentages of Treg, Th17, and double negative T cells, and lower numbers of double positive T cells compared to ileum. [J Crohns Colitis] Abstract A Distinct Plasmablast and Naive B-Cell Phenotype in Primary Immune Thrombocytopenia Experimental results indicated that an expanded population of CD95+ naive B-cells correlated with disease activity in immune thrombocytopenia patients regardless of treatment status. A population of CD21– naive B-cells was specifically expanded in autoantibody-positive immune thrombocytopenia patients. [Haematologica] Abstract | Full Article Human Umbilical Vein Endothelial Cells Foster Conversion of CD4+CD25−Foxp3− T cells into CD4+Foxp3+ Regulatory T Cells via Transforming Growth Factor-β Investigators studied whether human umbilical vein endothelial cells (HUVECs) induce the conversion of maternal T cells into regulatory T cells. Moreover, they assessed whether this response is changing according to the sex of the HUVECs. [Sci Rep] Full Article Propranolol Attenuates Surgical Stress-Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy The authors present the first report of the effects of perioperative propranolol and/or parecoxib on peripheral regulatory T cells (Tregs) in breast cancer patients. Propranolol administration, rather than parecoxib, attenuated elevation of Tregs, indicating the critical roles for catecholamines in surgery-induced promotion of Tregs. [J Immunol] Abstract Microarray Study Reveals a TGFβ-Dependent Mechanism of Fibrosis in Discoid Lupus Erythematosus Scientists sought to identify contradistinctive signaling pathways and cellular signatures between two types of lupus, with a focus on the molecular mechanisms leading to fibrosis. Discoid lupus samples displayed a significant CD4 T cell enrichment with an imbalance towards Th1 cytokine predominance and a relative increased FOXp3 response. [Br J Dermatol] Abstract PD-L1 Expression Is Associated with Tumor-Infiltrating T Cells and Favorable Prognosis in High-Grade Serous Ovarian Cancer Researchers investigated the primary source of programmed death ligand 1 (PD-L1) expression in epithelial ovarian cancer and its relationship to tumor-infiltrating lymphocytes and associated gene products. [Gynecol Oncol] Abstract Cistromic and Genetic Evidence that the Vitamin D Receptor Mediates Susceptibility to Latitude-Dependent Autoimmune Diseases Researchers determined the vitamin D receptor (VDR) cistrome in monocytes and monocyte-derived inflammatory (DC1) and tolerogenic dendritic cells (DC2). Of the nearly 11,000 VDR-binding peaks identified across the genome in DC1s, 1317 were shared with DC2s and 1579 with monocytes. [Genes Immun] Full Article Cyclosporine Restores Hematopoietic Function by Compensating for Decreased Tregs in Patients with Pure Red Cell Aplasia and Acquired Aplastic Anemia Investigators established a reliable method for measuring the regulatory T cell (Treg) count using FoxP3 and Helios expression as markers and determined the balance between Tregs and other helper T cell subsets in 16 pure red cell aplasia and 29 aplastic anemia patients. [Ann Hematol] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |