Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients To assess its molecular heterogeneity, scientists longitudinally profiled the blood transcriptome of 158 pediatric patients. They detected gradual enrichment of neutrophil transcripts during progression to active nephritis and distinct signatures in response to treatment in different nephritis subclasses. [Cell] Abstract | Graphical Abstract | Press Release Human Monocytes Engage an Alternative Inflammasome Pathway In human monocytes, lipopolysaccharide triggered an “alternative inflammasome” that relied on NLRP3-ASC-caspase-1 signaling, yet was devoid of any classical inflammasome characteristics including pyroptosome formation, pyroptosis induction, and K+ efflux dependency [Immunity] Abstract | Graphical Abstract | Press Release Alloantigen-Specific Regulatory T Cells Generated with a Chimeric Antigen Receptor The authors describe the creation of an HLA-A2–specific chimeric antigen receptor (A2-CAR) and its application in the generation of alloantigen-specific human regulatory T cells (Tregs). In mouse models, human A2-CAR–expressing Tregs were superior to Tregs expressing an irrelevant CAR at preventing xenogeneic graft-versus-host disease caused by HLA-A2+ T cells. [J Clin Invest] Full Article | Press Release CD300c Is Uniquely Expressed on CD56bright Natural Killer Cells and Differs from CD300a upon Ligand Recognition Researchers investigated the expression and function of CD300c on human NK cells. They demonstrated that IL-2 and IL-15 treatment significantly induce CD300c expression exclusively on CD56bright NK cells. [Sci Rep] Full Article Th17 Responses and Natural IgM Antibodies Are Related to Gut Microbiota Composition in Systemic Lupus Erythematosus Patients In vitro cultures revealed that microbiota isolated from systemic lupus erythematosus patient stool samples promoted lymphocyte activation and Th17 differentiation from naïve CD4+ lymphocytes to a greater extent than healthy control-microbiota. [Sci Rep] Full Article Immunostimulatory AdCD40L Gene Therapy Combined with Low-Dose Cyclophosphamide in Metastatic Melanoma Patients Local AdCD40L immunostimulatory gene therapy was evaluated in patients with malignant melanoma. The patients with the best survival developed the highest levels of activated T cells and experienced a pronounced decrease of intratumoral IL8. [Br J Cancer] Abstract CCR1 Antagonism Attenuates T Cell Trafficking to Omentum and Liver in Obesity-Associated Cancer Scientists demonstrated that T cells actively migrate to the secreted factors from the omentum and liver of esophagogastric adenocarcinoma patients and that both CD4+ and CD8+ T cells bearing the chemokine receptor CCR5 are significantly more prevalent in these tissues compared to matched blood. [Immunol Cell Biol] Full Article Enrichment of the Lung Microbiome with Oral Taxa Is Associated with Lung Inflammation of a Th17 Phenotype By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, scientists observed that pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. [Nat Microbiol] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |