NADPH Oxidase Deficiency Underlies Dysfunction of Aged CD8+ Tregs Scientists determined that older individuals fail to generate immunosuppressive CD8+CCR7+ Tregs, a defect that is even more pronounced in the age-related vasculitic syndrome giant cell arteritis. They identified deficiency of NADPH oxidase 2 as the molecular underpinning of CD8 Treg failure in the older individuals and in patients with giant cell arteritis. [J Clin Invest] Full Article | Press Release Neutrophil-Derived Alpha Defensins Control Inflammation by Inhibiting Macrophage mRNA Translation Scientists previously reported that alpha defensins, released from apoptotic human neutrophils, augmented the antimicrobial capacity of macrophages while also inhibiting the biosynthesis of proinflammatory cytokines. Here they showed that human neutrophil peptide 1 enters macrophages and inhibits protein translation without inducing the unfolded-protein response or affecting mRNA stability. [Proc Natl Acad Sci USA] Abstract | Press Release Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma Researchers investigated the genomic correlates of immune-cell infiltration and found that higher neoantigen load was positively associated with overall lymphocytic infiltration, tumor-infiltrating lymphocytes, memory T cells, and colorectal cancer-specific survival. [Cell Rep] Full Article | Graphical Abstract | Press Release MAIT Cells Reside in the Female Genital Mucosa and Are Biased towards IL-17 and IL-22 Production in Response to Bacterial Stimulation Investigators found that mucosal-associated invariant T (MAIT) cells and MR1+ antigen-presenting cells were present in the upper and lower female genital tract, with distinct tissue localization of MAIT cells in endometrium vs. cervix. [Mucosal Immunol] Full Article Mycobacteria-Responsive Sonic Hedgehog Signaling Mediates Programmed Death-Ligand 1- and Prostaglandin E2-Induced Regulatory T Cell Expansion Investigators demonstrated that mycobacteria-responsive sonic hedgehog signaling in human dendritic cells leads to programmed death ligand-1 expression and cyclooxygenase-2-catalyzed prostaglandin E2 that orchestrate mycobacterial infection-induced expansion of regulatory T cells . [Sci Rep] Full Article Human Macrophages Induce CD4+Foxp3+ Regulatory T Cells via Binding and Re-Release of TGF-β As a prerequisite for eventual translation of immunosuppressive macrophages (M2) therapy into clinical settings investigators studied the induction, stability and mechanism of generation of human induced regulatory T cells by M2 macrophages generated with IL-4/IL-10/TGF-β. [Immunol Cell Biol] Abstract IL-1β Limits the Extent of Human 6-Sulfo LacNAc Dendritic Cell (slanDC)-Mediated NK Cell Activation and Regulates CD95-Induced Apoptosis Previously, it was shown that natural killer (NK) cells communicate with slanDCs, which are able to stimulate NK cells in vitro. In this study, researchers investigated how slanDCs regulate the level of NK cell activation. [Cell Mol Immunol] Abstract OX40, PD-1 and CTLA-4 Are Selectively Expressed on Tumor-Infiltrating T Cells in Head and Neck Cancer Researchers investigated the expression of the known immune-modulatory proteins OX40, programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) in squamous cell carcinoma of the head and neck on different T-cell subsets of tumor-infiltrating lymphocytes to ascertain whether these proteins could potentially be targeted alone or in combination for future clinical trials. [Clin Transl Immunol] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |