miR-424(322) Reverses Chemoresistance via T-Cell Immune Response Activation by Blocking the PD-L1 Immune Checkpoint Scientists demonstrated that miR-424(322) regulates the PD-L1/PD-1 and CD80/CTLA-4 pathways in chemoresistant ovarian cancer. miR-424(322) was inversely correlated with PD-L1, PD-1, CD80 and CTLA-4 expression. [Nat Commun] Full Article NLRC5/MHC Class I Transactivator Is a Target for Immune Evasion in Cancer Scientists showed that the MHC class I transactivation pathway mediated by NLRC5 (NOD-like receptor family, caspase recruitment domain containing 5) constitutes a target for cancer immune evasion. [Proc Natl Acad Sci USA] Abstract | Press Release A Therapeutic Antibody for Cancer, Derived from Single Human B Cells The authors previously reported an association between autoantibodies against complement factor H (CFH) and early-stage lung cancer. In an effort to translate these findings into a biologic therapy for cancer, they isolated and expressed DNA sequences encoding high-affinity human CFH antibodies directly from single, sorted B cells obtained from patients with the antibody. [Cell Rep] Full Article | Graphical Abstract | Press Release HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2 Researchers showed a unique viral protein, vCXCL1, which targets three chemokine receptors: CXCR1 and CXCR2 expressed on neutrophils and CXCR1 and CX3CR1 expressed on NK cells. Although vCXCL1 attracted both cell types, neutrophils migrated faster and more efficiently than NK cells through the binding of CXCR2. [Cell Rep] Full Article | Graphical Abstract Exposure to Melan-A/MART-126-35 Tumor Epitope Specific CD8+ T Cells Reveals Immune Escape by Affecting the Ubiquitin-Proteasome System (UPS) Investigators showed that short-term co-culture of Melan-A/MART-1 tumor antigen-expressing melanoma cells with Melan-A/MART-126-35-specific cytotoxic T lymphocytes (CTL) led to resistance against CTL-induced lysis because of impaired Melan-A/MART-126-35 epitope processing. [Sci Rep] Full Article Activation-Dependent Cell Death of Human Monocytes Is a Novel Mechanism of Fine-Tuning Inflammation and Autoimmunity Given the fundamental role of monocyte activation in remodeling the early phases of inflammatory responses, researchers analyzed the GM-CSF/IFN-γ-induced activity of human monocytes in such a situation in vitro and in vivo. [Eur J Immunol] Abstract Dimethyl Fumarate Activates the Prostaglandin EP2 Receptor and Stimulates cAMP Signaling in Human Peripheral Blood Mononuclear Cells To determine if dimethyl fumarate (DMF) is able to activate signaling cascades that affect immune dysregulation, scientists treated human peripheral blood mononuclear cells with DMF. They discovered that DMF stimulates cyclic adenosine monophosphate production after one minute treatment in vitro. [Biochem Biophys Res Commun] Abstract T Cell Bim Levels Reflect Responses to Anti–PD-1 Cancer Therapy Scientists report that Bim is a downstream signaling molecule of the PD-1 pathway, and its detection in T cells is significantly associated with expression of PD-1 and effector T cell markers. [JCI Insight] Full Article | Press Release Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |