Human Immunology News 7.36 September 17, 2019 | |
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TOP STORYB Cells Sustain Inflammation and Predict Response to Immune Checkpoint Blockade in Human Melanoma Scientists showed that tumor associated B cells were vital to melanoma associated inflammation. Human B cells expressed pro- and anti-inflammatory factors and differentiated into plasmablast-like cells when exposed to autologous melanoma secretomes in vitro. [Nat Commun] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators showed that nicotinate phosphoribosyltransferase, detected by antibody-mediated assays and mass spectrometry, was an extracellular ligand for toll-like receptor 4 and a critical mediator of inflammation, acting as a damage-associated molecular pattern. [Nat Commun] Full Article Although TCR triggering alone was insufficient to drive sustained activation, TCR-triggered MAIT cells showed specific enrichment of tissue-repair functions at the gene and protein levels and in in vitro assays. [Cell Rep] Full Article | Graphical Abstract Epstein-Barr virus carriage promoted the concomitant activation of oxo-dNTP sanitization and purging pathways, including upregulation of the nucleoside triphosphatase mut-T homolog 1 and the DNA glycosylases 8-oxoguanine-glycosylase-1 and mut-Y homolog. [Oncogene] Abstract Using human peripheral and tumor-associated lymphocytes, researchers investigated how tumor-derived transforming growth factor-β (TGF-β) suppressed a key antitumor function of CD4+ T cells, interferon-γ (IFN-γ) production. [Sci Signal] Full Article Investigators found that elevated neutrophil extracellular trap levels in the sputum of chronic obstructive pulmonary disease patients were correlated with the circulating Th1 response, myeloid dendritic cell activation and airflow limitation. [Cell Death Dis] Full Article The authors report that the frequency of IL-10-producing regulatory B cells (Bregs) in human peripheral blood, spleens, and tonsils was similar, but they displayed heterogenous surface phenotypes. Nonetheless, CD24hiCD38hi transitional B cells and CD24hiCD27+ B cells were the major IL-10-producing B cells. [J Immunol] Abstract Increased Regulatory B Cells Are Involved in Immune Evasion in Patients with Gastric Cancer Scientists identified a role for regulatory B cells (Bregs) in immune evasion in gastric cancer (GC) patients. The frequency of peripheral Bregs was significantly higher in GC patients than in healthy controls. [Sci Rep] Full Article Activation of Mucosal-Associated Invariant T Cells in the Lungs of Sarcoidosis Patients Sarcoidosis patients with parenchymal infiltration in the lungs showed a significantly higher proportion and number of mucosal-associated invariant T cells in bronchoalveolar lavage fluid compared to patients without parenchymal infiltration. [Sci Rep] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSWhen Encephalitogenic T Cells Collaborate with Microglia in Multiple Sclerosis Scientists summarize the mechanisms and consequences of T cell-microglia interactions as identified with in vitro experiments and animal models, and discuss the challenges that arise when translating this preclinical knowledge to multiple sclerosis in humans. [Nat Rev Neurol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSCytoSorbents Corporation announced that Hannover Medical School in Germany will begin the first clinical study called CYTORELEASE, evaluating the use of CytoSorb in treating CRS and inflammation of the brain called CAR-related encephalopathy syndrome, following CAR-T cell immunotherapy. [CytoSorbents Corporation] Press Release Precision BioSciences, Inc. announced the FDA has accepted its Investigational New Drug (IND) application for PBCAR20A, the company’s second off-the-shelf chimeric antigen receptor (CAR) T cell therapy program. [Precision BioSciences, Inc.] Press Release | |
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POLICY NEWSNew Deals Could Help Scientific Societies Survive Open Access A project that included funders backing Plan S, the European-led effort to speed the transition to open access, released a set of contract templates and tips meant to help small, independent publishers reach deals with libraries that would eventually eliminate subscriptions while protecting revenue. [ScienceInsider] Editorial Trump’s Top Scientist Outlines Plan to Reduce Foreign Influence on US Research After months of outcry over whether the United States government is unfairly targeting foreign-born researchers over purported security breaches, President Donald Trump’s science adviser is launching an effort to strengthen national policies on research security. [Nature News] Editorial Science under Maximum Pressure in Iran From travel restrictions and publishing bans to currency collapse, the restoration of US sanctions has left researchers in Iran reeling. [The Scientist] Editorial
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EVENTSNEW Targeting Immunometabolism in Autoimmune Diseases and Inflammation Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Resarch Technician – Immune Cells (Flanders Institute for Biotechnology) Research Technologist (STEMCELL Technologies Inc.) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Scientist – Human Immunology (STEMCELL Technologies Inc.) Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.) Postdoctoral Researcher – Human Immunology (University of Gothenburg) Postdoctoral Position – Stem Cell Biology and Immunology (Columbia University) Postdoctoral Research Associate – Autoimmune Diseases (Benaroya Research Institute) Senior Scientific Researcher – Inflammatory Diseases (Genentech, Inc.) Research Assistant – Immunology (MD Anderson Cancer Center) Preclinical Scientist – Immunology (MiroBio) Postdoctoral Position – Immunology of Enteric Infections (University of Utah) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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