| Vol. 8.24 – 23 June, 2020 |
| |
|
|
| This Phase I trial assessed the ATR inhibitor M6620 as monotherapy and combined with carboplatin. Primary objectives were safety, tolerability, and maximum tolerated dose. [Journal of Clinical Oncology] |
| |
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models. [EMBO Journal] |
|
|
|
| Using an ecological population model, fitted to clinical tumor burden and immune cell abundance data from each patient, scientists found evidence of a strong tumor-circulating immune cell interaction in responder patients but not in those patients that progress on treatment. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Gingiva derived-mesenchymal stem cells limited the development of autoantibodies as well as proteinuria, decreases the frequency of plasma cells and lupus nephritis histopathological scores by directly suppressing B cells activation, proliferation and differentiation. [Journal of Autoimmunity] |
|
|
|
| lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13. [Journal of Immunology] |
|
|
|
| The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level. [Arthritis Research & Therapy] |
|
|
|
| There were 154 subjects included in this study: 60 with ulcerative colitis, 19 with Crohn’s disease and 75 in the control group. Colonic biopsy was performed in all subjects. Specimens were incubated with a primary anti-CD83 antibody. [Scientific Reports] |
|
|
|
| Scientists employed a RUNX1 knock-out mouse model and demonstrated by deep TCRβ sequencing, immunostaining and chromatin immunoprecipitation that RUNX1 binds to the initiation site of TCRβ rearrangement and its homozygous inactivation induced severe structural changes of the rearranged TCRβ gene, whereas heterozygous inactivation had almost no impact. [Scientific Reports] |
|
|
|
| Researchers evaluated activity of fresh and cryopreserved/thawed expanded and activated NK cells generated by interleukin (IL)-15, IL-2 and CD137L expansion. [CytoTherapy] |
| | |
|
|
| Main challenges to CAR-T cell therapy will be highlighted as well as strategies to structurally improve the CAR-T cell product, and thereby its efficacy and safety. [Leukemia] |
|
|
|
| Scientists evaluated activity of fresh and C/T EA NK cells generated by interleukin (IL)-15, IL-2 and CD137L expansion. [CytoTherapy] |
|
|
|
|
| With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science. [Nature News] |
|
|
|
| Arcutis Biotherapeutics, Inc. announced it had completed enrollment of its Phase II proof of concept clinical trial evaluating roflumilast foam as a potential treatment for seborrheic dermatitis. [Arcutis Biotherapeutics, Inc.] |
|
|
|
| Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online. [The Scientist] |
| |
|
|
| 2020-09-26 – 2020-09-26 Virtual |
|
|
|
|
| Ohio State University – Columbus, Ohio, United States |
|
|
|
| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
|
|
|
| Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
|
|
|
| Northwestern University – Chicago, Illinois, United States |
|
|
|
| AbCellera Biologics, Inc. – Vancouver, British Columbia, Canada |
|
|
|
|