 | | Vol. 8.38 – 29 September, 2020 |
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| Scientists report that macroautophagy, a catabolic membrane trafficking pathway that degrades cellular components through autophagosomes and lysosomes, mediated the downregulation of mammalian SIRT1 protein during senescence and in vivo aging.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified interleukin-8 as a biomarker for auxiliary diagnosis of thymoma. They found that IL-8 levels in naïve T cells were markedly elevated in patients with thymoma compared to those with other thymic tumors.
[Nature Communications] |
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| Serum antibody-epitope repertoire analysis was performed on patient serum to identify tumor-specific neoepitopes. Somatic mutation-specific neoepitopes were investigated by associating serum epitope enrichment scores with whole-genome sequencing results from paired solid-tumor metastasis biopsies and germline blood samples.
[Nature Communications] |
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| The associations between Regnase-1 in group 2 innate lymphoid cells (ILC2s) and human diseases were investigated by transcriptome analysis and a bleomycin-induced pulmonary fibrosis mouse model. The clinical significance of Regnase-1 in ILC2s was further assessed using patients-derived cells.
[European Respiratory Journal] |
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| Researchers showed that inhibition of N6‐methyladenosine mRNA modification by depletion of methyltransferases enhanced response to anti‐PD‐1 treatment in mismatch‐repair‐proficient or microsatellite instability‐low colorectal cancer and melanoma.
[EMBO Journal] |
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| Coculturing CD19-expressing β-like cells and CD19 CAR-T cells resulted in T cell-mediated β-like cell death with release of activated T cell cytokines.
[Cell Reports Medicine] |
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| A protein-based immunome-wide association study was performed to identify significantly enriched epitopes, and candidate serum antibodies enriched in select patients were validated by ELISA profiling.
[Clinical Cancer Research] |
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| | Scientists identified 9112 and 3929 differentially methylated CpG positions (DMPs) and differentially expressed genes (DEGs), respectively. These DMPs and DEGs were enriched in functional categories related to inflammation and T cell biology. [Genome Medicine] |
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| Normal human kidneys were obtained from radically nephrectomized patients with urogenital malignancy. Subsequently, human kidney immune cell subsets were analyzed using multicolor flow cytometry and compared with subsets from C57BL/6 or BALB/c mice under specific pathogen-free conditions.
[Scientific Reports] |
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| Scientists found that relative expression of MR1A/MR1B transcript was associated with the prevalence of MR1 + CD4/CD8 cells in the thymus.
[Scientific Reports] |
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| Researchers review recent technological advances that have facilitated the study of the immune system in humans. They discuss new insights and how these can affect the development of drugs and vaccines in the modern era.
[Science] |
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| The authors summarize the current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases.
[Signal Transduction and Targeted Therapy] |
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| Montefiore Health System and Albert Einstein College of Medicine have received a five-year, $111 million grant from the National Cancer Institute to lead this research consortium.
[Albert Einstein College of Medicine] |
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| October 13 – October 14
Virtual |
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| | Stockholm University – Stockholm, Sweden |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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| | Princess Margaret Cancer Center – Toronto, Ontario, Canada |
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| | STEMCELL Technologies – Flexible |
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