 | | Vol. 8.46 – 24 November, 2020 |
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| Researchers showed that human papillomavirus (HPV)-specific B cell responses were detectable in samples from patients with HPV-positive head and neck cancers, with active production of HPV-specific IgG antibodies in situ.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Liver biopsies from patients with alcoholic hepatitis revealed neutrophils in contact with bile ducts, which correlated with biochemical and histological parameters of cholestasis.
[Gut] |
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| Investigators report the outcome of 51 r/r B-ALL patients from a non-randomized, Phase II clinical trial. The primary outcome showed that the overall remission rate was 80.9%.
[Nature Communications] |
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| Researchers demonstrated that human CAR-T cells polarized and expanded under a Th9-culture condition have an enhanced antitumor activity against established tumors.
[Nature Communications] |
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| The authors used multiparameter flow cytometry and CITE-sequencing to investigate the cell type–specific responses of human peripheral blood dendritic cells and monocyte subsets to type I interferons, focusing on differential regulation of costimulatory molecules.
[Science Immunology] |
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| To comprehensively characterize the T-cell immune microenvironment of CDK12-deficient prostate cancers, subsets of immunosuppressive CD4+FOXP3– T-cells were increased compared to CDK12-proficient controls.
[Clinical Cancer Research] |
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| To study whether neuronal surface autoantibodies were more common in plasma of individuals with depression and anxiety than in controls, plasma samples of 819 individuals with a current diagnosis of depression and/or anxiety, 920 in remission and 492 individuals without these disorders were included in this study.
[Translational Psychiatry] |
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| Researchers explored the effect of chemotherapy on CD4+ and CD8+ cells in the bronchoalveolar lavage fluid of the healthy lung in patients treated with standard chemotherapy regimens.
[Scientific Reports] |
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| Investigators analyzed genome-wide sequences and structural alterations with pre- and on-therapy transcriptomic and T cell repertoire features in immunotherapy-naive melanoma patients treated with immune checkpoint blockade.
[Cell Reports Medicine] |
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| Scientists discuss recent data on a large number of cytokines that play important roles in regulating liver injury, inflammation, fibrosis, and regeneration, with a focus on interferons and T helper (Th) 1, Th2, Th9, Th17, interleukin (IL)-1 family, IL-6 family, and IL-20 family cytokines.
[Cellular & Molecular Immunology] |
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| The authors summarized the latest discoveries on the combination of nucleic acid-sensing immunity and immune checkpoint inhibitors in cancer immunotherapy.
[Signal Transduction and Targeted Therapy] |
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| Immunocore announced that its Phase III IMCgp100-202 clinical trial of tebentafusp vs. investigator choice in metastatic uveal melanoma has met the pre-defined boundaries for statistical significance of the primary endpoint of Overall Survival in its first pre-planned interim analysis conducted by the independent data monitoring committee.
[Immunocore] |
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| April 11 – April 13, 2021
San Diego, California, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | Queen’s University – Kingston, Ontario, Canada |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | LMU University Hospital Munich – Munich, Germany |
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