 | | Vol. 8.49 – 15 December, 2020 |
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| Using high-dimensional analysis of human adoptive T cell therapy products, scientists identified a memory-progenitor CD39-negative stem-like phenotype associated with complete cancer regression and tumor-infiltrating lymphocyte (TIL) persistence and a terminally differentiated CD39-positive state associated with poor TIL persistence.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used an integrated approach to characterize tissue-emigrant lineages in thoracic duct lymph. The most prevalent immune cells in human and non-human primate efferent lymph were T cells.
[Cell] |
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| Tissue resident memory T cells and lung resident macrophages were isolated using ex vivo lung perfusion and intra-perfusate labeled CD45 antibody.
[American Journal of Respiratory and Critical Care Medicine] |
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| The authors demonstrated that tumor-derived UBR5, an E3 ligase overexpressed in human ovarian cancer (OC) associated with poor prognosis, was essential for OC progression principally by promoting tumor-associated macrophage recruitment and activation via key chemokines and cytokines.
[Nature Communications] |
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| Scientists showed that D-mannose suppresses LPS-induced macrophage activation by impairing IL-1β production. In vivo, mannose administration improved survival in a mouse model of LPS-induced endotoxemia as well as decreased progression in a mouse model of DSS-induced colitis.
[Nature Communications] |
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| Using normal and malignant lymphocytes from humans, and the phosphodiesterase 4b knockout mouse, investigators found that cAMP induced PD-L1 transcription and protein expression.
[Leukemia] |
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| Researchers developed specific monoclonal antibodies directed to the junction region on the PAX3-FOXO1 fusion protein. Two monoclonal antibodies, PFM.1 and PFM.2, were developed and able to immunoprecipitate in vitro-translated PAX3-FOXO1 and cellular PAX3-FOXO1 from FP-RMS cells.
[Modern Pathology] |
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| Scientists determined whether the expression of functionally relevant TGF-β-regulated molecules was altered in Tregs from patients with multiple sclerosis.
[Multiple Sclerosis Journal] |
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| The authors outline the clinical differences between persistent inflammatory refractory rheumatoid arthritis (PIRRA) and non-inflammatory refractory rheumatoid arthritis, the genetic and epigenetic mechanisms and immune pathways that might contribute to the immunopathogenesis of recalcitrant synovitis in PIRRA.
[Nature Reviews Rheumatology] |
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| One of the major insights produced by researching the molecular origins and mechanisms of diffuse large B-cell lymphoma (DLBCL) is that DLBCL almost always stems from genetic damage that occurs during the germinal center reaction, which is required for the production of high-affinity antibodies.
[Blood Cancer Journal] |
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| Scientists discuss results from experimental model systems demonstrating that modulating the immune response can negatively affect metastasis formation.
[British Journal of Cancer] |
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| Cabaletta Bio, Inc. announced that the first patient has been dosed in the DesCAARTesâ„¢ Phase I clinical trial of DSG3-CAART for the treatment of patients with mucosal-dominant pemphigus vulgaris.
[Cabaletta Bio, Inc. (GlobeNewswire, Inc.)] |
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| Fate Therapeutics, Inc. announced positive interim data from their dose escalation Phase I study of FT516 in combination with rituximab for patients with relapsed/refractory B-cell lymphoma.
[Fate Therapeutics, Inc.] |
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| Arbutus Biopharma Corporation announced additional clinical data from an ongoing Phase Ia/Ib clinical trial with AB-729, its proprietary GalNAc delivered RNA interference compound.
[Arbutus Biopharma Corporation] |
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| March 23 – 24, 2021
Virtual |
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| | UIC Anesthesiology – Chicago, Illinois, United States |
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| | Scripps Research Institute – La Jolla, California, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | University of California Irvine – Irvine, California, United States |
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