Human Immunology News Volume 9.31 | Aug 10 2021

    By
    Justin.choi
    -
    0
    44






    2021-08-10 | HIN 9.31


    Human Immunology News by STEMCELL Technologies
    Vol. 9.31 – 10 August, 2021
    TOP STORY

    Human TBK1 Deficiency Leads to Autoinflammation Driven by TNF-Induced Cell Death

    Researchers demonstrated that TANK binding kinase 1 (TBK1) loss resulted in hypomorphic but sufficient IFN-I induction via RIG-I/MDA5, while the system retained near intact IL-6 induction through NF-κB.
    [Cell]

    AbstractGraphical Abstract

    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC

    The authors found that SHP2 inhibitor treatment depleted alveolar and M2-like macrophages, induced tumor-intrinsic CCL5/CXCL10 secretion and promoted B and T lymphocyte infiltration in Kras- and Egfr-mutant non-small cell lung cancer.
    [Cancer Discovery]

    Abstract

    The CD155/TIGIT Axis Promotes and Maintains Immune Evasion in Neoantigen-Expressing Pancreatic Cancer

    Using multiple preclinical models of neoantigen-expressing pancreatic adenocarcinoma (PDAC), scientists demonstrated that intratumoral neoantigen-specific CD8+ T cells adopted multiple states of dysfunction, resembling those in tumor-infiltrating lymphocytes of PDAC patients.
    [Cancer Cell]

    AbstractGraphical Abstract

    Tumor-Conditional IL-15 Pro-Cytokine Reactivates Anti-Tumor Immunity with Limited Toxicity

    Investigators developed a next-generation IL-15 that was activated inside the tumor microenvironment.
    [Cell Research]

    Abstract

    Directly Reprogrammed Natural Killer Cells for Cancer Immunotherapy

    Scientists showed that human somatic cells could be directly reprogrammed into natural killer cells with a CD56brightCD16bright phenotype using pluripotency transcription factors and an optimized reprogramming medium.
    [Nature Biomedical Engineering]

    Abstract

    CD70-Specific CAR T Cells Have Potent Activity against Acute Myeloid Leukemia without HSC Toxicity

    To target CD70 on acute myeloid leukemia cells, researchers generated a panel of CD70-CAR T cells that contained a common single-chain variable fragment for antigen detection, but differed in size and flexibility of the extracellular spacer and in the transmembrane and the costimulatory domains.
    [Blood]

    Abstract

    FcγR Engagement Reprograms Neutrophils into Antigen Cross-Presenting Cells That Elicit Acquired Anti-Tumor Immunity

    Investigators showed that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converted neutrophils into neutrophil-derived cells with properties of dendritic cells (DCs) that activated T cells to levels observed with classical DCs.
    [Nature Communications]

    Full Article

    Chronological Genome and Single-Cell Transcriptome Integration Characterizes the Evolutionary Process of Adult T Cell Leukemia-Lymphoma

    Scientists developed and utilized a capture-based sequencing panel, which covered host hotspot genes and the full-length genome of human T cell leukemia virus type-1, to investigate the clonal architecture of adult T cell leukemia-lymphoma.
    [Nature Communications]

    Full Article

    Degranulation Enhances Presynaptic Membrane Packing, Which Protects NK Cells from Perforin-Mediated Autolysis

    The authors demonstrated that natural killer cells were protected from perforin-mediated autolysis by densely packed and highly ordered presynaptic lipid membranes, which increased packing upon synapse formation.
    [PLOS Biology]

    Full Article

    Genomic Instability in Lower-Grade Glioma: Prediction of Prognosis Based on LncRNA and Immune Infiltration

    Investigators divided patients into genome stable and unstable groups according to the somatic mutation count, and then found that the expression of CDC20 was positively correlated with genomic instability.
    [Molecular Therapy-Oncolytics]

    Abstract

    Tunable Heat Shock Protein-Mediated NK Cell Responses Are Orchestrated by STAT1 in Antigen Presenting Cells

    Scientists investigated the cellular response of different antigen presenting cells to the prototypical immunogenic heat shock protein, gp96, in the context of Th1 immunity.
    [Scientific Reports]

    Full Article

    SepMateâ„¢ PBMC Isolation
    REVIEWS

    Targeting the DNA Damage Response in Immuno-Oncology: Developments and Opportunities

    Investigators discuss the interplay between the DNA damage response and anticancer immunity and highlight how this dynamic interaction contributes to shaping tumor immunogenicity.
    [Nature Reviews Cancer]

    Abstract

    Maternal Immune Activation and Neuroinflammation in Human Neurodevelopmental Disorders

    The authors focus on the emerging human evidence for an association between maternal immune activation and childhood neurodevelopmental disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder and Tourette syndrome.
    [Nature Reviews Neurology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Revolo Biotherapeutics Announces Clinical Trial Authorization to Initiate Phase II Trial of ‘1104 in Allergic Disease in the UK

    Revolo Biotherapeutics announced receipt of Clinical Trial Authorization by the Medicines and Healthcare Products Regulatory Agency in the UK to evaluate safety and efficacy of its first-in-class peptide for the treatment of allergic disease, ‘1104, in a Phase II allergen sensitivity study.
    [Revolo Biotherapeutics]

    Press Release

    FEATURED EVENT

    DGI German Society for Immunogenetics

    September 15 – 16, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – CAR T-Cell Studies

    Baylor College of Medicine – Houston, Texas, United States

    Scientist – Autoimmune and Inflammatory Diseases

    Amgen – San Francisco, California, United States

    Postdoctoral Scholar – Immunology, Cancer Immunotherapy, and Protein Engineering

    University of California Irvine – Irvine, California, United States

    Postdoctoral Researcher – Stem Cells and Immunotherapy

    University of Wisconsin–Madison – Madison, Wisconsin, United States

    Research Scientist – Cancer Immunotherapy Drug Discovery

    Incyte – Wilmington, Delaware, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter