Human Immunology News Volume 9.39 | Oct 5 2021

    By
    Justin.choi
    -
    0
    117






    2021-10-05 | HIN 9.39


    Human Immunology News by STEMCELL Technologies
    Vol. 9.39 – 5 October, 2021
    TOP STORY

    Inhibition of the BTK-IDO-mTOR Axis Promotes Differentiation of Monocyte-Lineage Dendritic Cells and Enhances Anti-Tumor T Cell Immunity

    Researchers examined how targeting pathways that inhibited the differentiation of inflammatory myeloid cells affected antitumor immunity.
    [Immunity]

    AbstractGraphical Abstract


    This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.
    PUBLICATIONSRanked by the impact factor of the journal

    CD177 Modulates the Function and Homeostasis of Tumor-Infiltrating Regulatory T Cells

    Using single-cell RNA sequencing of immune cells from renal clear cell carcinoma patients, investigators identified two distinct transcriptional fates for tumor-infiltrating regulatory T cells, Fate-1 and Fate-2.
    [Nature Communications]

    Full Article

    CD137 Costimulation Counteracts TGFβ Inhibition of NK-Cell Antitumor Function

    Researchers demonstrated that the anti-CD137 agonist urelumab could overcome TGFβ-mediated inhibition of human NK-cell proliferation and antitumor function.
    [Cancer Immunology Research]

    Abstract

    γδ T Cells Support Antigen-Specific αβ T Cell-Mediated Antitumor Responses during BCG Treatment for Bladder Cancer

    Scientists showed that Bacillus Calmette-Guérin (BCG) increased the number of tumor antigen-specific αβ T cells in patients with bladder cancer.
    [Cancer Immunology Research]

    Abstract

    Distinct Single-Component Adjuvants Steer Human DC-Mediated T-Cell Polarization via Toll-Like Receptor Signaling toward a Potent Antiviral Immune Response

    Investigators assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Reverted Exhaustion Phenotype of Circulating Lymphocytes as Immune Correlate of Anti-PD1 First-Line Treatment in Hodgkin Lymphoma

    Hodgkin lymphoma patients showed a decreased CD4 T cell fraction, a higher percentage of effector-memory T cells and higher expression of activation markers at baseline.
    [Leukemia]

    Full Article

    Anti-CD40 Antibodies Fused to CD40 Ligand Have Superagonist Properties

    The authors showed that direct fusion of CD40L to certain agonistic anti-CD40 antibodies conferred superagonist properties, reducing the dose required for efficacy, notably greatly increasing total cytokine secretion by human dendritic cells.
    [Journal of Immunology]

    Full Article

    TIGIT Induces (CD3+) T Cell Dysfunction in Colorectal Cancer by Inhibiting Glucose Metabolism

    Scientists found that the proportion of CD3+TIGIT+ T cells was increased in peripheral blood and cancer tissue in colorectal cancer patients when compared with the healthy donors.
    [Frontiers in Immunology]

    Full Article

    CD47-Targeted Cancer Immunogene Therapy: Secreted SIRPα-FC Fusion Protein Eradicates Tumors by Macrophage and NK Cell Activation

    Researchers developed a plasmid-vector encoding for the secreted fusion protein sCV1-hIgG1, comprising of highly efficient CD47-blocking moiety CV1 and Fc domain of human IgG1 with maximized immune activation.
    [Molecular Therapy-Oncolytics]

    Abstract

    Identification of Immune-Related Subtypes of Colorectal Cancer to Improve Antitumor Immunotherapy

    Investigators applied a non-negative matrix factorization algorithm to establish a robust immune molecular classification system for colorectal cancer.
    [Scientific Reports]

    Full Article

    Request your free copy of the 'Human Immune Cytokines' Wallchart
    REVIEWS

    Glial and Myeloid Heterogeneity in the Brain Tumor Microenvironment

    The authors discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
    [Nature Reviews Cancer]

    Abstract

    The Interplay of Immunology and Cachexia in Infection and Cancer

    Investigators discuss the complex immunological context of cachexia, a systemic catabolic syndrome that depletes both fat and muscle mass with profound consequences for patient prognosis.
    [Nature Reviews Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    MoonLake Immunotherapeutics AG and Helix Acquisition Corp. Announce Business Combination Agreement to Create Publicly Listed Biotechnology Company Advancing Tri-Specific Nanobody® Sonelokimab

    MoonLake Immunotherapeutics AG and Helix Acquisition Corp. announced they have entered into a definitive business combination agreement.
    [MoonLake Immunotherapeutics AG]

    Press Release

    FEATURED EVENT

    Maternal-Fetal Newborn Immunity

    October 28 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Department Head – Microbiology, Immunology and Pathology

    Colorado State University – Fort Collins, Colorado, United States

    Doctoral Researcher – Immunology

    Helmholtz Centre for Infection Research – Braunschweig, Germany

    Research Associate – Therapeutic Immunology & Infectious Disease

    University of Cambridge – Cambridge, England, United Kingdom

    Scientist – Cancer Cell Signaling

    The University of New Mexico – Albuquerque, New Mexico, United State

    Postdoctoral Fellow – Molecular and Cellular Oncology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter