 | | Vol. 9.42 – 26 October, 2021 |
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| Researchers developed PHAGE-Assay for Transposase-Accessible Chromatin (ATAC), a massively parallel droplet-based method that used phage displaying, engineered, camelid single-domain antibodies for simultaneous single-cell measurements of protein levels and chromatin accessibility profiles, and mitochondrial DNA-based clonal tracing.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified lineage-specific DNA methylation signatures of six immune cell types from human peripheral blood and determined their relationship to other epigenetic and transcriptomic patterns.
[Immunity] |
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| The authors performed whole-genome sequencing of 150 adult T cell leukemia/lymphoma (ATL) cases and revealed the overarching landscape of genetic alterations in ATL.
[Blood] |
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| Researchers used single-cell mass cytometry to study signal transduction pathways such as the JAK-STAT, PI3K-AKT-mTOR and MEK-ERK pathways in 16 diagnostic and 5 relapsed T cell acute lymphoblastic leukemia primary samples and investigated the in vitro response of cells to interleukin-7 and the inhibitor BEZ-235.
[Haematologica] |
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| The authors elucidated the impact of neurotrophin-3 on human monocyte and T cell activation as well as cytokine production ex vivo after stroke.
[Experimental Neurology] |
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| Investigators explored the role of glycolysis inhibition by 2-Deoxy-D-glucose on regulating immune responses of oral lichen planus-derived T cells.
[Journal of Cellular and Molecular Medicine] |
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| CircRNA microarray was used to observe the expression of candidate circRNAs in CD4+ T cells collected from different groups. Real-time PCR and Western blot were conducted to observe the changes in the expression of different miRNAs, mRNAs and proteins.
[Molecular Medicine] |
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| Scientists retrospectively analyzed 26 patients with primary thyroid lymphomas and 16 patients with benign lymphoproliferative lesions.
[Endocrine Journal] |
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| Lower Foxp3 and higher Bcl-6, ICOS, and PD-1 mRNA expression levels were found in patients with dilated cardiomyopathy (DCM). Plasma interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-21 levels were significantly increased in DCM cases.
[Brazilian Journal of Medical and Biological Research] |
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| The authors reported the identification of tumoral ring finger protein 2 (RNF2), the core subunit of polycomb repressor complex 1, as a negative regulator of antitumor immunity in various human cancers, including breast cancer.
[Nature Cancer] |
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| Toll-like receptors, cytokine receptors, and T and B cell receptors have been shown to activate multiple downstream metabolic pathways. However, how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well understood.
[Cellular & Molecular Immunology] |
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| The authors introduce neutrophil extracellular trap (NET) formation and discuss the possible neutrophil extracellular trap-related mechanisms in wound healing.
[Cell Death & Disease] |
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| Questions remain about the nature of the immune activation, the network of underlying mechanisms involved, and the breadth of impact across behavioral phenotypes.
[Biological Psychiatry-Cognitive Neuroscience and Neuroimaging] |
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| Novartis announced that the CANOPY-1 Phase III study did not demonstrate the statistically significant primary endpoints of overall survival and progression-free survival in patients treated with canakinumab combined with pembrolizumab plus platinum-based doublet chemotherapy, compared to patients receiving placebo in combination with pembrolizumab plus platinum-based doublet chemotherapy.
[Novartis] |
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| Ultimovacs ASA announced that the company’s universal cancer vaccine, UV1, will be investigated in a new Phase II clinical trial in combination with pembrolizumab in non-small cell lung cancer.
[Ultimovacs ASA] |
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| November 28 – December 1, 2021
Edinburgh, Scotland, United Kingdom |
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| | Calgary, Alberta, Canada – University of Calgary |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Calgary, Alberta, Canada – University of Calgary |
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| Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States |
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