Immune Regulation News Volume 11.41 | Oct 17 2023

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    Laurisa Dohm
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    2023-10-17 | HIN 11.41


    Human Immunology News by STEMCELL Technologies
    Vol. 11.41 – 17 October, 2023
    TOP STORY

    Probiotic-Guided CAR-T Cells for Solid Tumor Targeting

    The authors developed a platform of probiotic-guided CAR-T cells, in which tumor-colonizing probiotics released synthetic targets that labeled tumor tissue for CAR-mediated lysis in situ.
    [Science]

    AbstractPress Release
    Checking your cell quality doesn’t have to be difficult. Genetic screening with the hPSC Genetic Analysis Kit
    PUBLICATIONSRanked by the impact factor of the journal

    Progenitor-Like Exhausted SPRY1+CD8+ T Cells Potentiate Responsiveness to Neoadjuvant PD-1 Blockade in Esophageal Squamous Cell Carcinoma

    Researchers performed single-cell RNA-sequencing of tumors from patients with esophageal squamous cell carcinoma undergoing neoadjuvant immune checkpoint blockade, revealing a subset of exhausted CD8+ T cells expressing SPRY1 that displayed a progenitor exhausted T cell phenotype.
    [Cancer Cell]

    Full ArticleGraphical Abstract

    Ibrutinib-Based Therapy Reinvigorates CD8 T Cells Compared to Chemoimmunotherapy: Immune-Monitoring From the E1912 Trial

    Scientists performed longitudinal immunophenotypic and functional analysis of pre- and on-treatment peripheral blood samples from patients in the Phase III E1912 trial comparing ibrutinib-rituximab to fludarabine, cyclophosphamide, and rituximab.
    [Blood]

    Abstract

    Microenvironmental Network of Clonal CXCL13+CD4+ T Cells and Regulatory T Cells in Pemphigus Chronic Blisters

    Immunologic properties of the skin were analyzed by immunofluorescence staining, bulk and single-cell RNA and TCR sequencing, and a highly multiplex imaging technique known as CO-Detection by indEXing.
    [Journal Of Clinical Investigation]

    AbstractGraphical Abstract

    Donor-Derived Regulatory Dendritic Cell Infusion Modulates Effector CD8+ T Cell and NK Cell Responses after Liver Transplantation

    Researchers performed clinical monitoring and comprehensive assessment of peripheral and allograft tissue immune cell populations in regulatory dendritic cells-infused live-donor liver transplant recipients up to 12 months after transplant.
    [Science Translational Medicine]

    Abstract

    The CD4+ T Cell Repertoire Specific for Citrullinated Peptides Shows Evidence of Immune Tolerance

    Investigators used fluorophore-conjugated HLA-DR tetramers containing citrullinated peptides from human cartilage intermediate layer protein, fibrinogen, vimentin, or enolase 1 to track cognate CD4+ T cells.
    [Journal Of Experimental Medicine]

    Abstract

    First-in-Human immunoPET Imaging of COVID-19 Convalescent Patients Using Dynamic Total-Body PET and a CD8-Targeted Minibody

    A 89Zr-labeled CD8-targeted minibody was used with total-body positron emission tomography (PET) in healthy individuals and COVID-19 convalescent patients. Kinetic modeling results aligned with T cell–trafficking effects expected in lymphoid organs.
    [Science Advances]

    Full Article

    Characterization of the Antispike IgG Immune Response to COVID-19 Vaccines in People with a Wide Variety of Immunodeficiencies

    In a prospective cohort of 195 immune-deficient/disordered people and 35 healthy volunteers, antispike immunoglobulin G (IgG) was detected in 88% of immune-deficient/disordered people after dose two, increasing to 93% by six months after dose three.
    [Science Advances]

    Full Article

    Immune Signatures of Checkpoint Inhibitor-Induced Autoimmunity – A Focus on Neurotoxicity

    In this observational cohort study, investigators collected serum and peripheral blood samples from 34 consecutive cancer patients with neurologic immune-related adverse events (irAE-n) during acute illness, and 49 cancer control patients without irAE-n.
    [Neuro-Oncology]

    AbstractGraphical Abstract
    Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.
    REVIEWS

    Stem-Like Exhausted and Memory CD8+ T Cells in Cancer

    Scientists discuss key similarities and differences in the regulation and function of stem-like exhausted CD8+ T cells and memory CD8+ T cells, and consider their context-specific contributions to protective immunity in diverse outcomes of cancer.
    [Nature Reviews Cancer]

    Abstract

    Cancer Cell-Intrinsic Mechanisms Driving Acquired Immune Tolerance

    The authors focus on T cells as key effectors of anti-cancer immunity and argue that cancer cells evade immune destruction by gaining control over pathways that usually serve to maintain physiological tolerance to self.
    [Immunity]

    Full Article

    The Evolving Landscape of B Cells in Cancer Metastasis

    Scientists review the complex roles of B cells in metastasis, delineating the heterogeneity of B cell activity and subtypes by metastatic site, antibody class, antigen, and molecular phenotype.
    [Cancer Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Sotio Stops IL-15 Trials As Cytokine Falls Short in Solid Tumors, Dealing Fresh Blow to Once-Hot Mechanism

    A look at interim data on nanrilkefusp alfa, also known as SOT101, has revealed “insufficient efficacy to warrant further development in larger randomized trials” in the settings targeted to date, prompting Sotio to immediately stop enrollment in three studies.
    [Fierce Biotech]

    Editorial
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    JOB OPPORTUNITIES

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Doctoral Positions – Biomedical Research

    Berlin Institute of Health at Charité – Berlin, Germany

    Clinical Research Coordinator – Rheumatology

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Researcher – Cancer Immunotherapy Research

    University of Turku – Turku, Finland

    Postdoctoral Fellow – Airway Inflammation

    Institut Necker Enfants-Malades – Paris, France

    > See All Jobs

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