 | | Vol. 12.23 – 26 June, 2020 |
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| The authors report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
[Nature Communications] |
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| Scientists showed that the Na+/Ca2+ exchanger 1 played a critical role in high salt-triggered Na+ influx, concomitant Ca2+ efflux, and subsequent augmented NFAT5 accumulation.
[PLoS Biology] |
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| Investigators examined whether Ling‐Zhi 8 (rLZ‐8) would ameliorate pulmonary inflammation in a model of asthma‐like mice.
[Journal of Leukocyte Biology] |
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| Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells.
[Nature Communications] |
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| Scientists introduced a collagen-based 3D matrix to embed Raw264.7 cell line and primary rat bone marrow-derived macrophages.
[Scientific Reports] |
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| Cytotoxicity of different hyperthermic temperatures and treatment durations were tested in normal murine macrophages and breast cancer cell lines.
[International Journal of Hyperthermia] |
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| Investigators demonstrate that a disrupted gut microbiota could be created in a mouse model of hemophilia A using a broad-spectrum antibiotic.
[Blood Advances] |
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| Investigators demonstrated that dendritic cells represented a critical source of PD-L1, despite being vastly outnumbered by PD-L1+ macrophages.
[Nature Cancer] |
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| Investigators discuss how the role of NK cells evolves with tumor progression, presenting new opportunities to target NK cell function to enhance cancer immunotherapy response rates across a more diverse range of cancers.
[Nature Reviews Cancer] |
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| Scientists describe the thymic development of NK T cells, mucosal-associated invariant T (MAIT) cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.
[Nature Reviews Immunology] |
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| Pre-clinical immuno-oncology models for studying metastases have long been limited to syngeneic or carcinogenesis-inducible models that have murine cancer and immune cells.
[Cancers] |
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| On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News] |
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| A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist] |
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| Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider] |
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| Aduro Biotech, Inc. announced that the first patient with IgA nephropathy has been dosed in a Phase I clinical trial of BION-1301, an investigational humanized IgG4 monoclonal antibody that blocks APRIL binding to both the BCMA and TACI receptors.
[Audro Biotech, Inc.] |
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| | University of Luxembourg – Luxembourg, Luxembourg |
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| | Lund University – Lund, Sweden |
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| | King’s College London – London, United Kingdom |
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| | Lund University – Scania, Sweden |
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| | Aarhus University – Aarhus C, Denmark |
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