Immune Regulation News Volume 12.39 | Oct 16 2020

May 12, 2022

IRN 12.39 | Oct 16 2020

Immune Regulation News by STEMCELL Technologies

Vol. 12.39 – 16 October, 2020

TOP STORY

CAR-T
Cells Targeting a Nucleophosmin Neoepitope Exhibit Potent Specific Activity in Mouse Models of Acute Myeloid Leukemia

Scientists report a human single-chain variable fragment, identified via yeast surface display, that specifically bound to the NPM1c epitope–HLA-A2 complex but not to HLA-A2 or to HLA-A2 loaded with control peptides
[Nature Biomedical Engineering]

Abstract

Request your free copy of the 'Human Immune Cytokines' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Uncoupling
Interferon Signaling and Antigen Presentation to Overcome Immunotherapy Resistance Due to JAK1 Loss in Melanoma

Investigators generated models of interferon signaling defects in B16 murine melanoma observed in patients with acquired resistance to immune checkpoint blockade.
[Science Translational Medicine]

Full Article

SUSA2
Is an F-Box Protein Required for Autoimmunity Mediated by Paired NLRs SOC3-CHS1 and SOC3-TN2

Scientists report the identification of suppressor of Senescence-Associated E3 Ubiquitin Ligase 1 (SAUL1) 2 (susa2) and susa3 from the saul1-1 suppressor screen.
[Nature Communications]

Full Article

Biodiversity
Intervention Enhances Immune Regulation and Health-Associated Commensal Microbiota among Daycare Children

Researchers conducted the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children.
[Science Advances]

Full Article

Rapamycin
Prevents Spontaneous Abortion by Triggering Decidual Stromal Cell Autophagy-Mediated NK Cell Residence

Scientists observed that the increased macroautophagy/autophagy of decidual stromal cells during decidualization, facilitated the adhesion and retention of decidual NK cells during normal pregnancy.
[Autophagy]

Abstract

Expression
of Leukotriene B4 Receptor 1 Defines Functionally Distinct DCs That Control Allergic Skin Inflammation

By generating Leukotriene B4 (LTB4)-producing enzyme LTA4H knockout mice and CD11c promoter-driven Cre recombinase-expressing BLT1 conditional knockout mice, the authors showed that the migration of BLT1hi dendritic cells exacerbated allergic contact dermatitis.
[Cellular & Molecular Immunology]

Full Article

IL-22
Receptor Signaling in Paneth Cells Is Critical for Their Maturation, Microbiota Colonization, Th17-Related Immune Responses, and Anti-Salmonella Immunity

Using novel Paneth cell-specific IL-22Ra1 knockout mice, scientists showed that IL-22 signaling in Paneth cells was required for small intestinal host defense. They showed that Paneth cell maturation, antimicrobial effector function, expression of specific WNTs, and organoid morphogenesis were dependent on cell-intrinsic IL-22Ra1 signaling.
[Mucosal Immunology]

Full Article

Combination of rAd-p53 In Situ
Gene Therapy and Anti-PD-1 Antibody Immunotherapy Induced Anti-Tumor Activity in Mouse Syngeneic Urogenital Cancer Models

The authors undertook a novel combination therapy using rAd-p53 in situ gene therapy and immunotherapy with immune checkpoint inhibitor anti-PD-1 antibody for urogenital cancers. Three mouse syngeneic tumor cell lines, TRAMP-C2 (prostate), MBT-2 (bladder) and Renca (kidney) were used.
[Scientific Reports]

Full Article

Formaldehyde
Exposure Induces Regulatory T Cell-Mediated Immunosuppression via Calcineurin-NFAT Signalling Pathway

Researchers investigated the effects of formaldehyde exposure on splenic immune responses wherein helper T cells become activated and differentiate into effector T and regulatory T cells.
[Scientific Reports]

Full Article

GD2-Specific
CAR T Cells Encapsulated in an Injectable Hydrogel Control Retinoblastoma and Preserve Vision

Investigators generated GD2-specific chimeric antigen receptor T lymphocytes and locally delivered them to mice with an in situ grafting retinoblastoma .
[Nature Cancer]

Abstract

Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.

REVIEWS

Environmental Pollutants and the Immune Response

Scientists summarize the major environmental pollutants that are attracting wide-ranging concern and the molecular basis underlying their effects on the immune system.
[Nature Immunology]

Abstract

INDUSTRY AND POLICY NEWS

TREMFYA^® (Guselkumab) Induces Clinical and Endoscopic Improvements in Patients with Moderately to Severely Active Crohn’s Disease based on Interim Results from Phase II Study

The Janssen Pharmaceutical Companies of Johnson & Johnson announced Phase II interim data from the GALAXI 1 study, which showed TREMFYA® demonstrated results at week 12 in adult patients with moderately to severely active Crohn’s disease with inadequate response or intolerance to conventional therapies and/or biologics.
[Johnson & Johnson (BusinessWire, Inc.)]

Press Release

Evelo
Biosciences Completes Enrollment in Phase Ib Clinical Trial Cohort Evaluating EDP1815 in Atopic Dermatitis

Evelo Biosciences, Inc. completed enrollment of 24 patients in the Phase Ib clinical trial cohort evaluating EDP1815 in mild to moderate atopic dermatitis. EDP1815 is an investigational oral biologic in development for the treatment of inflammatory diseases
[Evelo Biosciences, Inc.]

Press Release

Inventiva Receives FDA Breakthrough Therapy Designation for Lead Drug Candidate Lanifibranor in NASH

Inventiva announced that the FDA has granted Breakthrough Therapy designation to lanifibranor, the company’s lead drug candidate, for the treatment of NASH.
[Inventiva]

Press Release

FEATURED EVENT

CAR-T
Cells Targeting a Nucleophosmin Neoepitope Exhibit Potent Specific Activity in Mouse Models of Acute Myeloid Leukemia

Uncoupling
Interferon Signaling and Antigen Presentation to Overcome Immunotherapy Resistance Due to JAK1 Loss in Melanoma

SUSA2
Is an F-Box Protein Required for Autoimmunity Mediated by Paired NLRs SOC3-CHS1 and SOC3-TN2

Biodiversity
Intervention Enhances Immune Regulation and Health-Associated Commensal Microbiota among Daycare Children

Rapamycin
Prevents Spontaneous Abortion by Triggering Decidual Stromal Cell Autophagy-Mediated NK Cell Residence

Expression
of Leukotriene B4 Receptor 1 Defines Functionally Distinct DCs That Control Allergic Skin Inflammation

IL-22
Receptor Signaling in Paneth Cells Is Critical for Their Maturation, Microbiota Colonization, Th17-Related Immune Responses, and Anti-Salmonella Immunity

Combination of rAd-p53 In Situ
Gene Therapy and Anti-PD-1 Antibody Immunotherapy Induced Anti-Tumor Activity in Mouse Syngeneic Urogenital Cancer Models

Formaldehyde
Exposure Induces Regulatory T Cell-Mediated Immunosuppression via Calcineurin-NFAT Signalling Pathway

GD2-Specific
CAR T Cells Encapsulated in an Injectable Hydrogel Control Retinoblastoma and Preserve Vision

Environmental Pollutants and the Immune Response

TREMFYA^® (Guselkumab) Induces Clinical and Endoscopic Improvements in Patients with Moderately to Severely Active Crohn’s Disease based on Interim Results from Phase II Study

Evelo
Biosciences Completes Enrollment in Phase Ib Clinical Trial Cohort Evaluating EDP1815 in Atopic Dermatitis

Inventiva Receives FDA Breakthrough Therapy Designation for Lead Drug Candidate Lanifibranor in NASH

The
Evolving Tumor Microenvironment In Cancer Progression: Mechanisms And Emerging Therapeutic Opportunities

> See All Events

Postdoctoral Fellow – Cancer Immunology and Immunotherapy

Podcast
Host – The Immunology Podcast

Postdoctoral
Position – Infectious Diseases and Immunology

Assistant/Associate Professor of Immunology

Professorship
– Vaccine Research and Immunology

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