Immune Regulation News Volume 13.04 | Feb 5 2021

May 12, 2022

119

IRN 13.04 | Feb 5 2021

Immune Regulation News by STEMCELL Technologies

Vol. 13.04 – 5 February, 2021

TOP STORY

Dynamic Regulation of T^FH Selection during the Germinal Centre Reaction

Researchers report on the dynamic behaviour of T follicular helper (T^FH) cell clones during the germinal centre reaction.
[Nature]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Mutant p53 Suppresses Innate Immune Signaling to Promote Tumorigenesis

The authors report a mechanism by which mutant p53 suppressed both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance.
[Cancer Cell]

Abstract Graphical Abstract

Regulation
of Tumor Immune Suppression and Cancer Cell Survival by CXCL1/2 Elevation in Glioblastoma Multiforme

Scientists showed that elevation of CXCL1 or CXCL2 facilitated myeloid cell migration and simultaneously disrupted CD8⁺ T cell accumulation at tumor sites, causing accelerated tumor progression.
[Science Advances]

Abstract

Noncoding
RNA Processing by DIS3 Regulates Chromosomal Architecture and Somatic Hypermutation in B Cells

Investigators developed a mouse model with a conditional allele to study the RNA exosome catalytic subunit DIS3.
[Nature Genetics]

Abstract

A
Small-Molecule P2RX7 Activator Promotes Anti-Tumor Immune Responses and Sensitizes Lung Tumor to Immunotherapy

Researchers developed a chemical positive modulator of the purinergic P2RX7 receptor that potentiated αPD-1 treatment to effectively control the growth of lung tumors in transplantable and oncogene-induced mouse models and triggered long lasting antitumor immune responses.
[Nature Communications]

Full Article

CD4
Derived Double Negative T Cells Prevent the Development and Progression of Nonalcoholic Steatohepatitis

Adoptive transfer of CD4⁺ T cells converted double negative T cells protected mice from diet-induced liver fat accumulation, lobular inflammation and focal necrosis.
[Nature Communications]

Full Article

Cooperative
Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade

Scientists showed that enapotamab vedotin, an antibody-drug conjugate targeting AXL, effectively targeted tumors that displayed insensitivity to immunotherapy or tumor-specific T cells in several melanoma and lung cancer models.
[Cancer Research]

Abstract

Nod1
Promotes Colorectal Carcinogenesis by Regulating the Immunosuppressive Functions of Tumor-Infiltrating Myeloid Cells

Investigators demonstrated the immunosuppressive potential of Nod1, the bacterial sensor of diaminopimelic acid-containing muramyl peptides.
[Cell Reports]

Full Article Graphical Abstract

The
E Protein-TCF1 Axis Controls γδ T Cell Development and Effector Fate

The authors revealed a regulatory axis where T cell receptor signaling controls TCF1 expression through an E-protein-bound regulatory element in the Tcf7 locus, and this axis regulated both γδ T lineage commitment and effector fate.
[Cell Reports]

Full Article Graphical Abstract

Modulation
of Intratumoral Myeloid Cells, the Hallmark of the Anti-Tumor Efficacy Induced by a Triple Combination: Tumor-Associated Peptide, TLR-3 Ligand and α-PD-1

Scientists compared the kinetics of immune cells in the tumour microenvironment upon treatment with immunotherapy combinations with different anti-tumour efficacies in the non-inflamed tumour model TC-1/A9.
[British Journal of Cancer]

Abstract

The
Bovine Dialysable Leukocyte Extract IMMUNEPOTENT CRP Induces Immunogenic Cell Death in Breast Cancer Cells Leading to Long-Term Antitumour Memory

Immunogenicity of IMMUNEPOTENT CRP-induced cell death was evaluated in vitro, analyzing the principal biochemical characteristics of immunogenic cell death in MCF-7, MDA-MB-231 and 4T1 cells.
[British Journal of Cancer]

Abstract

LncRNA
HLA-F-AS1 Promotes Colorectal Cancer Metastasis by Inducing PFN1 in Colorectal Cancer-Derived Extracellular Vesicles and Mediating Macrophage Polarization

The effect of profilin 1 (PFN1)-treated macrophages on colorectal cancer cell proliferation and migration was observed by subcutaneous tumorigenesis experiments in nude mice.
[Cancer Gene Therapy]

Abstract

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REVIEWS

Regulation of Inflammation by the Antioxidant Haem Oxygenase 1

The authors discuss the impact of haem oxygenase 1 induction in specific immune cell populations and provide new insights into the immunomodulation that accompanies haem catabolism, including its relationship to immunometabolism.
[Nature Reviews Immunology]

Abstract

The Roles of T Cells in Bladder Pathologies

Scientists suggest that T cell behavior might be influenced by resident T cell interactions with the bladder microbiota and other immunostimulants.
[Trends in Immunology]

Abstract

INDUSTRY AND POLICY NEWS

Immudex Launches dCODE Dextramer^® (RiO), a New Reagent Compatible with BD Rhapsody™ Single Cell Analysis System

Immudex announced the launch of dCODE Dextramer^® reagents. These DNA barcoded MHC Dextramer^® reagents are designed to be compatible with the BD Rhapsody™ system to be used for multiplexing, allowing the identification of many different T-cell specificities in the same sample.
[Immudex (Life Science Newswire, Inc.)]

Press Release

FEATURED EVENT

Dynamic Regulation of T^FH Selection during the Germinal Centre Reaction

Mutant p53 Suppresses Innate Immune Signaling to Promote Tumorigenesis

Regulation
of Tumor Immune Suppression and Cancer Cell Survival by CXCL1/2 Elevation in Glioblastoma Multiforme

Noncoding
RNA Processing by DIS3 Regulates Chromosomal Architecture and Somatic Hypermutation in B Cells

A
Small-Molecule P2RX7 Activator Promotes Anti-Tumor Immune Responses and Sensitizes Lung Tumor to Immunotherapy

CD4
Derived Double Negative T Cells Prevent the Development and Progression of Nonalcoholic Steatohepatitis

Cooperative
Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade

Nod1
Promotes Colorectal Carcinogenesis by Regulating the Immunosuppressive Functions of Tumor-Infiltrating Myeloid Cells

The
E Protein-TCF1 Axis Controls γδ T Cell Development and Effector Fate

Modulation
of Intratumoral Myeloid Cells, the Hallmark of the Anti-Tumor Efficacy Induced by a Triple Combination: Tumor-Associated Peptide, TLR-3 Ligand and α-PD-1

The
Bovine Dialysable Leukocyte Extract IMMUNEPOTENT CRP Induces Immunogenic Cell Death in Breast Cancer Cells Leading to Long-Term Antitumour Memory

LncRNA
HLA-F-AS1 Promotes Colorectal Cancer Metastasis by Inducing PFN1 in Colorectal Cancer-Derived Extracellular Vesicles and Mediating Macrophage Polarization

Regulation of Inflammation by the Antioxidant Haem Oxygenase 1

The Roles of T Cells in Bladder Pathologies

Immudex Launches dCODE Dextramer^® (RiO), a New Reagent Compatible with BD Rhapsody™ Single Cell Analysis System

The 3^rd
UK Cellular Microbiology Network

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Researcher – Translational Cell Assays

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Research Fellow – Autophagy in Prostate Cancer

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Fellow – Osteoarthritis

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Researcher – Neuroimmunology

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