| Vol. 13.08 – 5 March, 2021 |
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| Researchers showed that the concentration of sphingosine 1-phosphate (S1P) increased in lymph nodes during an immune response. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists established that nutrient uptake and signaling were key determinants of T cell fate and shape the quantity and quality of memory T cell responses. [Cell] |
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| The authors developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate. [Nature Immunology] |
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| Researchers examined the aetiology of the Flt3 ligand (Flt3L)-mediated increase of type 1 conventional dendritic cells. [Nature Cell Biology] |
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| Scientists demonstrated that both local tumor ionizing radiation and anti–programmed death ligand 1 treatment decreased tumor-induced Ter cell abundance in the mouse spleen and ARTN secretion outside the irradiation field in an interferon- and CD8+ T cell–dependent manner. [Science Translational Medicine] |
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| The authors investigated CX3C chemokine receptor 1, a marker of T-cell differentiation, as a predictive correlate of response to immune checkpoint inhibitor therapy. [Nature Communications] |
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| Researchers showed conditional deletion of METTL3 in CD4+ T cells impaired TFH differentiation and germinal center responses in a cell-intrinsic manner in mice. [Nature Communications] |
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| Investigators showed that optic atrophy 1 (OPA1) was necessary for thymocyte maturation at the double negative 3 stage when rearrangement of the T cell receptor β locus occurred. [Cell Death & Differentiation] |
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| Researchers showed that 1,2,4-TTB markedly suppressed nigericin- or ATP-induced NOD-like receptor (NLR) family pyrin domain-containing-3 (NLRP3) inflammasome activation, thus decreased caspase-1 activation and IL-1β secretion in immortalized murine bone marrow-derived macrophages and in primary mouse microglia. [Acta Pharmacologica Sinica] |
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| Scientists focused on gene expression differences between early retinal states that ultimately led to normal development, late onset retinoblastoma, or rapid bilateral retinoblastoma tumors. [Laboratory Investigation] |
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| The authors showed that IP2 increased pioneer translation product-derived antigen presentation in cancer cells in vitro and impaired tumor growth in vivo. [Communications Biology] |
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| A progressive and consistent reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngeneic mice. [Scientific Reports] |
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| Scientists describe how the immune system relays information to the nervous system and how cytokine signalling occurs in neurons. [Nature Reviews Immunology] |
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| Recent advances in real-time in situ imaging of effector T cell migratory behaviour have revealed a great degree of mechanistic plasticity that enables effector T cells to push and squeeze their way through inflamed tissues. [Nature Reviews Immunology] |
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| Be The Match BioTherapies announced an expansion of their multi-year partnership with Orchard Therapeutics to include supply chain services in support of the upcoming commercial launch of Libmeldy™ (autologous CD34+ cells encoding the ARSA gene), Orchard’s gene therapy recently approved in Europe for the treatment of early-onset metachromatic leukodystrophy. [Be The Match BioTherapies (BusinessWire, Inc)] |
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| March 23 – 25, 2021 Virtual |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| University of Toronto – Toronto, Canada |
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| Duke University – Durham, North Carolina, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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