Immune Regulation News Volume 13.08 | Mar 5 2021

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    IRN 13.08 | Mar 5 2021


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.08 – 5 March, 2021
    TOP STORY

    Monocyte-Derived S1P in the Lymph Node Regulates Immune Responses
    Researchers showed that the concentration of sphingosine 1-phosphate (S1P) increased in lymph nodes during an immune response.
    [Nature]
    Abstract
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    In Vivo CRISPR Screening Reveals Nutrient Signaling Processes Underpinning CD8+ T Cell Fate Decisions
    Scientists established that nutrient uptake and signaling were key determinants of T cell fate and shape the quantity and quality of memory T cell responses.
    [Cell]
    AbstractGraphical Abstract

    Effector and Stem-Like Memory Cell Fates Are Imprinted in Distinct Lymph Node Niches Directed by CXCR3 Ligands
    The authors developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate.
    [Nature Immunology]
    Abstract

    Single-Cell Analyses Reveal the Clonal and Molecular Aetiology of Flt3L-Induced Emergency Dendritic Cell Development
    Researchers examined the aetiology of the Flt3 ligand (Flt3L)-mediated increase of type 1 conventional dendritic cells.
    [Nature Cell Biology]
    Abstract

    Radiotherapy and Immunotherapy Converge on Elimination of Tumor-Promoting Erythroid Progenitor Cells through Adaptive Immunity
    Scientists demonstrated that both local tumor ionizing radiation and anti–programmed death ligand 1 treatment decreased tumor-induced Ter cell abundance in the mouse spleen and ARTN secretion outside the irradiation field in an interferon- and CD8+ T cell–dependent manner.
    [Science Translational Medicine]
    Abstract

    T-Cell CX3CR1 Expression as a Dynamic Blood-Based Biomarker of Response to Immune Checkpoint Inhibitors
    The authors investigated CX3C chemokine receptor 1, a marker of T-cell differentiation, as a predictive correlate of response to immune checkpoint inhibitor therapy.
    [Nature Communications]
    Full Article

    METTL3-Dependent m6A Modification Programs T Follicular Helper Cell Differentiation
    Researchers showed conditional deletion of METTL3 in CD4+ T cells impaired TFH differentiation and germinal center responses in a cell-intrinsic manner in mice.
    [Nature Communications]
    Full Article

    Deletion of the Mitochondria-Shaping Protein Opa1 during Early Thymocyte Maturation Impacts Mature Memory T Cell Metabolism
    Investigators showed that optic atrophy 1 (OPA1) was necessary for thymocyte maturation at the double negative 3 stage when rearrangement of the T cell receptor β locus occurred.
    [Cell Death & Differentiation]
    Full Article

    1,2, 4-Trimethoxybenzene Selectively Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Autoimmune Encephalomyelitis
    Researchers showed that 1,2,4-TTB markedly suppressed nigericin- or ATP-induced NOD-like receptor (NLR) family pyrin domain-containing-3 (NLRP3) inflammasome activation, thus decreased caspase-1 activation and IL-1β secretion in immortalized murine bone marrow-derived macrophages and in primary mouse microglia.
    [Acta Pharmacologica Sinica]
    Abstract

    Retinoblastoma Tumor Cell Proliferation Is Negatively Associated with an Immune Gene Expression Signature and Increased Immune Cells
    Scientists focused on gene expression differences between early retinal states that ultimately led to normal development, late onset retinoblastoma, or rapid bilateral retinoblastoma tumors.
    [Laboratory Investigation]
    Abstract

    Isoginkgetin Derivative IP2 Enhances the Adaptive Immune Response against Tumor Antigens
    The authors showed that IP2 increased pioneer translation product-derived antigen presentation in cancer cells in vitro and impaired tumor growth in vivo.
    [Communications Biology]
    Full Article

    Serial Transplantation Unmasks Galectin-9 Contribution to Tumor Immune Escape in the MB49 Murine Model
    A progressive and consistent reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngeneic mice.
    [Scientific Reports]
    Full Article
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    REVIEWS

    Neuromodulation by the Immune System: A Focus on Cytokines
    Scientists describe how the immune system relays information to the nervous system and how cytokine signalling occurs in neurons.
    [Nature Reviews Immunology]
    Abstract

    The Spatio-Temporal Control of Effector T Cell Migration
    Recent advances in real-time in situ imaging of effector T cell migratory behaviour have revealed a great degree of mechanistic plasticity that enables effector T cells to push and squeeze their way through inflamed tissues.
    [Nature Reviews Immunology]
    Abstract
    INDUSTRY AND POLICY NEWS

    Be The Match BioTherapies® Announces Expansion of Multi-Year Strategic Alliance with Orchard Therapeutics to Support European Commercial Launch of Libmeldy™
    Be The Match BioTherapies announced an expansion of their multi-year partnership with Orchard Therapeutics to include supply chain services in support of the upcoming commercial launch of Libmeldy™ (autologous CD34+ cells encoding the ARSA gene), Orchard’s gene therapy recently approved in Europe for the treatment of early-onset metachromatic leukodystrophy.
    [Be The Match BioTherapies (BusinessWire, Inc)]
    Press Release
    FEATURED EVENT

    FcRn-Targeted Therapies for Autoimmune Disorders
    March 23 – 25, 2021
    Virtual

    > See All Events
    JOB OPPORTUNITIES

    Postdoc/Research Scientist – Immunology
    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Research Fellow – RNA Biology
    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow Position – B Cell Biology
    University of Toronto – Toronto, Canada

    Postdoctoral Associate Position – Tumor Immunology/Immunotherapy
    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Immunogenetics and Tumor Immunology
    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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