 | | Vol. 13.14 – 23 April, 2021 |
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| Researchers showed that NKG2A genetic ablation in dams mated with wild-type males caused suboptimal maternal vascular responses in pregnancy, accompanied by perturbed placental gene expression, reduced fetal weight, greater rates of smaller fetuses with asymmetric growth, and abnormal brain development.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated a rationale to combine interleukin-15 superagonist and glucocorticoid-induced tumor necrosis factor receptor–related protein agonist with subablative radiotherapy in mesothelioma.
[Science Translational Medicine] |
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| The authors identified aberrant ZAP70 expression as a common feature in a broad range of B cell malignancies. They validated SYK as the kinase that sets the thresholds for negative selection of autoreactive and premalignant clones.
[Molecular Cell] |
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| Using intravital microscopy of ischemic hind limb muscle in mice, and confocal microscopy of human tissues from amputated legs, scientists found that macrophages accumulated perivascularly in ischemic muscles, where they expressed high levels of iNOS.
[Circulation Research] |
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| Overexpression of ARIH1 suppressed tumor growth and promoted cytotoxic T cell activation in wild-type, but not in immunocompromised mice, highlighting the role of ARIH1 in anti-tumor immunity.
[Nature Communications] |
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| The authors showed that resident F4/80HighCD206− peritoneal macrophages promptly accumulate on the lesion and form a ‘macrophage barrier’ to shield fibrin clots in place of the lost mesothelium in mice.
[Nature Communications] |
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| The IOX1 and DOX combination greatly promoted T cell infiltration and activity and significantly reduced tumor immunosuppressive factors.
[Nature Communications] |
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| Using humanized mice that colonization of distant visceral organs with melanoma was dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising.
[Journal of Experimental Medicine] |
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| In SLE patients, decreased expression of CCL2 on mesenchymal stem cells prevented inhibition of B-cell proliferation, causing the characteristic autoimmune phenotype.
[Cell Death & Differentiation] |
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| Investigators used melanoma tumors arising from a genetically engineered mouse model to evaluate the efficacy of an anti-mouse PD-L1 antibody similar to the anti-human PD-L1 antibodies durvalumab and atezolizumab.
[Molecular Cancer Research] |
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| Scientists provide an overview of the use of NK cells in cancer immunotherapy, their current status in clinical trials, as well as the design and implementation of delivery technologies.
[Cancer Gene Therapy] |
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| Monopteros Therapeutics, Inc. announced that it has dosed the first patient in its Phase I/Ib dose escalation and cohort expansion clinical trial. The trial aims to evaluate the safety, efficacy, and pharmacology of MPT-0118 and to demonstrate the reprogramming of regulatory T cells.
[Monopteros Therapeutics, Inc. (BusinessWire, Inc.)] |
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| May 17 – 21, 2021
Virtual |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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