 | | Vol. 13.15 – 30 April, 2021 |
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| Investigators showed that ablation of meningeal lymphatic vessels in 5xFAD mice (a mouse model of amyloid deposition that expressed five mutations found in familial Alzheimer’s disease) worsened the outcome of mice treated with anti-Aβ passive immunotherapy.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using multi-omics approaches, researchers revealed that metastasis-like primary tumors arose from IT via dedifferentiation following a reverse trajectory along the developmental pathway of islet B-cells, which resulted in the acquisition of a progenitor-like molecular phenotype.
[Cancer Discovery] |
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| The authors investigated how adrenoceptor signaling influenced leukocyte behavior. Intravital two-photon imaging after injection of noradrenaline revealed transient inhibition of CD8+ and CD4+ T cell locomotion in tissues.
[Immunity] |
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| Scientists investigated the impact of the local arm of the sympathetic nervous system in an inflammatory response in the colon. Intra-rectal insertion of an optogenetic probe in mice engineered to express channelrhodopsin-2 in tyrosine hydroxylase cells activated colonic sympathetic fibers.
[Immunity] |
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| Researchers identified the m6A demethylase FTO as an essential epitranscriptomic regulator utilized by tumors to escape immune surveillance through regulation of glycolytic metabolism.
[Cell Metabolism] |
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| Investigators used single-cell RNA sequencing of human and mouse lymph nodes to identify a subset of T cell–zone fibroblastic reticular cells defined by the expression of Gremlin1 in both species.
[Nature Immunology] |
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| Scientists showed that a distinct subset of tumor-associated macrophages, endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1, played a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition.
[Nature Immunology] |
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| The authors report that dietary supplementation with conjugated linoleic acid, a mixture of linoleic acid isomers, ameliorated CNS autoimmunity in a spontaneous mouse model of multiple sclerosis, accompanied by an attenuation of intestinal barrier dysfunction and inflammation as well as an increase in intestinal myeloid-derived suppressor-like cells.
[Brain] |
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| Researchers showed that Bruton’s tyrosine kinase-deficiency promoted inflammatory bowel disease progression in a mouse model of colitis. The increased colitis susceptibility of BTK-deficient mice was not caused by gut microbiota changes but rather arose from enhanced pro-inflammatory Th1 response.
[Cell Death & Disease] |
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| Scientists propose strategies for combining suitable vaccine platforms with novel immunomodulatory approaches and standard-of-care treatments for overcoming tumor resistance and enhancing clinical efficacy.
[Nature Reviews Cancer] |
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| The authors compare the mechanisms by which fibroblasts control local immune responses, as well as the factors regulating their inflammatory and suppressive profiles, in different tissues and pathological settings.
[Nature Reviews Immunology] |
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| Researchers discuss changes in the cells of the salivary gland epithelium in primary Sjögren syndrome, and the proposed interplay of these cells with environmental stimuli and the immune system.
[Nature Reviews Rheumatology] |
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| CARISMA Therapeutics, Inc. announced it has established a multi-year scientific collaboration with Bruce Blazar, MD, Regents Professor of Pediatrics, Division of Blood and Marrow Transplantation and Cellular Therapy at the University of Minnesota to investigate and develop allogeneic macrophage therapies.
[CARISMA Therapeutics, Inc. (PR Newswire LLC.)] |
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| May 18 – 19, 2021
Virtual |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Helmholtz Zentrum München – Neuherberg (bei München), Germany |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
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