 | | Vol. 13.17 – 14 May, 2021 |
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| Investigators showed that the azo dyes Red 40 and Yellow 6, the most abundant food colorants in the world, could trigger an IBD-like colitis in mice conditionally expressing interluekin (IL)-23, or in two additional animal models in which IL-23 expression was augmented.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To clarify which T cell subsets were involved in the development of destructive thyroiditis (thyroid-irAE), a mouse model of thyroid-irAE was analyzed.
[Science Translational Medicine] |
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| Investigators showed that the CD200-CD200R pathway restrained activation of CD200R+ lesional macrophages, their production of CCR2 ligands, and monocyte recruitment in vitro and in vivo in an air pouch model.
[Circulation Research] |
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| The authors combined transcriptional and epigenetic profiling to identify a human effector Treg cell signature.
[Nature Communications] |
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| Researchers developed conjugate vaccines against mouse IL-4 and IL-13, and demonstrated their prophylactic and therapeutic efficacy in reducing IgE levels, AHR, eosinophilia and mucus production in mouse models of asthma analyzed up to 15 weeks after initial vaccination.
[Nature Communications] |
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| Investigators found that aging, known to negatively impact immune responses, impaired asymmetric cell division in murine CD8+ T cells, and that this phenotype could be rescued by transient mTOR inhibition.
[Nature Communications] |
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| Researchers reported PD-1 signaling regulated the initial T cell receptor antigen recognition manifested in a smaller spreading area, fewer molecular bonds formed, and shorter bond lifetime of T cell interaction with peptide-major histocompatibility complex in the presence than absence of PD-1 ligand-1 in a manner dependent on Src homology region 2 domain-containing phosphatases and Leukocyte C-terminal Src kinase.
[Nature Communications] |
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| The authors demonstrated that preoperative ProIL2 and surgery treatment was vastly superior to ProIL2 or surgery alone in eradicating metastases and could also prevent cancer recurrence in mammary tumor-bearing mice.
[Nature Communications] |
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| Scientists reported that blocking PD-1/PD-L1 interaction between myeloid-derived suppressor cells and B cells could reverse the immunosuppressive functions of PD-1−PD-L1+ Bregs.
[Cell Death & Disease] |
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| Investigators used multiphoton intravital microscopy to examine the role of RGD-binding integrins and signaling through phosphoinositide 3-kinase P110δ in intradermal Treg migration in resting and inflamed skin.
[Frontiers in Immunology] |
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| The authors provide an overview of chemokine biology, with a particular focus on the genetic and epigenetic regulation of chemokine transcription as well as on the cell type-specific production of chemokines by liver cells and liver-associated immune cells.
[Nature Reviews Gastroenterology & Hepatology] |
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| Investigators present an integrated view of fibroblast-macrophage interactions that is centered on the CSF1-CSF1R axis and discuss how additional molecular programs linking these cell types can underpin disease onset, progression, and resolution.
[Immunity] |
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| Scientists summarize the current evidence for epigenetic regulation of immune-related pathways in cancer and describe bioinformatics tools, informative visualization techniques, and resources to help decipher the cancer epigenome.
[Experimental & Molecular Medicine] |
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| Connect Biopharma Holdings Limited announced that the first patient has been dosed in a Phase II trial evaluating CBP-201 in adults with moderate-to-severe persistent asthma.
[Connect Biopharma Holdings Limited] |
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| Auris Medical Holding Ltd. announced that it has reached the midpoint for enrollment in Part B of its Phase II proof-of-concept trial of AM-125 in the treatment of acute peripheral vertigo.
[Auris Medical Holding Ltd.] |
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| | BioMed X Institute – Heidelberg, Germany |
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| | Universit̩ Libre de Bruxelles РBrussels, Belgium |
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| | Trinity College Dublin – Dublin, Republic of Ireland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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