 | | Vol. 13.20 – 4 June, 2021 |
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| B cells reached the meninges from the calvaria through specialized vascular connections. This calvarial–meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that secreted gelsolin, an extracellular protein, decreased DNGR-1 binding to F-actin and cross-presentation of dead cell-associated antigens by type 1 conventional dendritic cells.
[Cell] |
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| The proteomics studies on liver co-cultures implicated the activated hepatic stellate cells-secreted chemokine CXCL12 in the induction of NK cell quiescence through its cognate receptor CXCR4.
[Nature] |
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| Old and young mouse brains, metastatic and naïve, were analyzed by flow cytometry. Immune populations were depleted using antibodies or a colony stimulating factor-1 receptor (CSF-1R) inhibitor, and brain metastasis assays were conducted.
[Clinical Cancer Research] |
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| Investigators reported that the retention of lymphoid tissue inducer (LTi)-like cells in conventional solitary intestinal lymphoid tissue was essential for controlling LTi-like cell function and is maintained by expression of the chemokine receptor CXCR5. Deletion of Cxcr5 functionally unleashed LTi-like cells in a cell intrinsic manner, leading to uncontrolled IL-17 and IL-22 production.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists performed whole-exome sequencing of patients with immune dysregulation disorders and identified two patients with previously undescribed mutations in LRRC32, which encoded glycoprotein A repetitions predominant.
[Cellular & Molecular Immunology] |
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| Researchers showed that expression of Ascl2 transcription factor was upregulated in germinal center (GC) B cells. Ectopic expression of Ascl2 promoted GC B cell development and enhanced antibody production and affinity maturation.
[Cell Reports] |
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| Mice with an inducible NK-specific deletion of Cox10, which encoded a component of electron transport chain complex IV, were generated to investigate the role of oxidative phosphorylation in NK cells during murine cytomegalovirus infection.
[Cell Reports] |
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| Cross-sections from injured and non-injured human spinal cords were immunolabeled for α-synuclein. This showed robust α-synuclein accumulation in profiles resembling axons and astrocytes in tissue surrounding the injury, revealing that α-synuclein markedly aggregated in traumatically injured human spinal cords.
[Scientific Reports] |
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| Using RNA sequencing (RNA-seq) analysis, researchers showed that exon 3 and exons 7–10 of GPC2 were expressed in cancer but was minimally expressed in normal tissues.
[Cell Reports Medicine] |
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| The authors discuss the early life dialogue between the oral mucosa and the microbiota, with particular emphasis on the central role the multilayer epithelium plays to protect the oral mucosa.
[Trends in Immunology] |
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| Virios Therapeutics, Inc. dosing of the first patient in its Phase IIb clinical trial, referred to as (Fibromyalgia Outcome Research Trial Evaluating Synergistic Suppression of HSV-1) FORTRESS, evaluating IMC-1 in patients with fibromyalgia.
[Virios Therapeutics, Inc.] |
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| 4D pharma plc announced the completion of its target enrollment of 30 patients for Part A of its Phase I/II clinical trial of MRx-4DP0004 in patients with partly-controlled asthma.
[4D pharma plc] |
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| June 28 – 30, 2021
Virtual |
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| | Shanghai Immune Therapy Institute – Shanghai, China |
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| | Salk Institute – La Jolla, California, United States |
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| Gilead Sciences, Inc. – Foster City, California, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | University of Virginia – Charlottesville, Virginia, United States |
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