 | | Vol. 13.27 – 23 July, 2021 |
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| The authors reported the discovery of an intrinsic counter regulatory mechanism in colitis pathogenesis that may be targeted for intestinal bowel disease treatment.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that maternal cecal microbiota transfer to NOD mice after early-life antibiotic perturbation largely rescued the induced type 1 diabetes enhancement.
[Cell Host & Microbe] |
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| Researchers tested whether silencing netrin-1 in advanced atherosclerosis could resolve arterial inflammation and regress plaques.
[Circulation Research] |
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| Single-cell RNA sequencing and protected bone marrow chimeras demonstrated that ingestion of lipids led to specific transcriptional activation of a population of resident macrophages expressing Lyve1, Tim4, and ABCA1.
[Nature Communications] |
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| Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103−CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.
[Nature Communications] |
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| In mice, lack of PTPN22 augmented antitumor activity with greater infiltration and activation of macrophages, natural killer cells, and T cells.
[Journal of Clinical Investigation] |
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| Starting with the observation that T cells moved more quickly through mouse tumors as residence time increased and they progressed towards exhaustion, the authors elaborated a non-stimulatory live-biopsy method for real-time study of T cell behaviors within individual patient tumors.
[Journal of Clinical Investigation] |
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| Investigators identified a novel role for oncogenic Hedgehog signaling in programming signature metabolic circuitries that regulated alternative polarization of tumor-associated macrophages.
[Cancer Research] |
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| Genetic deletion or methylation of DNA-sensing/IFN genes or CCL5 chemokine was identified as a potential mechanism to attenuate T cell inflammation.
[Cell Reports] |
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| Using a model of dermal inflammation, researchers demonstrated that SPNS2 supplies the S1P that guided T cells out of lymph nodes with an ongoing immune response.
[Cell Reports] |
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| Investigators used whole-genome analyses to show that the transcriptional program and epigenetic features of Treg cells were attenuated in the absence of Tet2 and Tet3.
[EMBO Reports] |
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| Increasing or decreasing Syk activity by stimulating the γδ T cell receptor (TCRγδ) or inhibiting Syk, respectively, substantially reduced γδ17 cell numbers.
[Science Signaling] |
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| Neutrophils are immune cells with unusual biological features that furnish potent antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and eukaryotic organisms very efficiently.
[Immunity] |
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| In self-limiting inflammation, the evolving inflammatory response is coupled to distinct processes that promote the resolution of inflammation and restore homeostasis.
[Nature Reviews Nephrology] |
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| Scientists review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis.
[Journal of Experimental Medicine] |
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| NGM Biopharmaceuticals, Inc. announced it has completed enrollment in the Phase II CATALINA study, which will the safety and efficacy of intravitreal injections of NGM621 in patients with geographic atrophy secondary to age-related macular degeneration.
[NGM Biopharmaceuticals, Inc.] |
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| The Lupus Foundation of America announced six recipients of the 2021 Gina M. Finzi Memorial Student Summer Fellowship Program. The fellowship program provides grant and mentorship support for young scientists and plays an important role in establishing the next generation of lupus researchers and the future of the lupus research field.
[The Lupus Foundation of America] |
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| September 15 – 16, 2021
Virtual |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| Columbia University Medical Center – New York City, New York, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Tübingen University – Tuebingen, Germany |
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| | Roswell Park – Colorado Springs, Colorado, United States |
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