Immune Regulation News Volume 13.34 | Sep 10 2021

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    2021-09-10 | IRN 13.34


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.34 – 10 September, 2021
    TOP STORY

    Deoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype

    Levels of eIF5AHyp were found to be increased in adipose tissue macrophages from obese mice and in murine macrophages activated to a proinflammatory M1-like state.
    [Cell Metabolism]

    Full ArticleGraphical Abstract
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    IL-33 Causes Thermogenic Failure in Aging by Expanding Dysfunctional Adipose ILC2

    Investigators defined alterations in the adipose-resident immune system and identify that type 2 innate lymphoid cells (ILC2s) were lost in aging.
    [Cell Metabolism]

    AbstractGraphical Abstract

    Microglia Promote Autoimmune Inflammation via the Noncanonical NF-κB Pathway

    Data suggest that following their initial central nervous system infiltration, T cells activate the microglial noncanonical NF-κB pathway, which synergizes with the T cell-derived cytokine granulocyte-macrophage colony-stimulating factor to induce expression of chemokines involved in the second-wave of T cell recruitment and disease progression.
    [Science Advances]

    Full Article

    Adoptive Immunotherapy with Transient Anti-CD4 Treatment Enhances Anti-Tumor Response by Increasing IL-18Rαhi CD8+ T Cells

    Using murine melanoma, the combined effect of cyclophosphamide preconditioning, anti-CD4 treatment, CD4, and ex vivo primed tumor-reactive CD8+ T cell infusion was presented.
    [Nature Communications]

    Full Article

    Multiplexed Single-Cell Analysis of Organoid Signaling Networks

    Researchers presented a multiplexed mass cytometry protocol for single-cell analysis of post-translational modification signaling and cell states in organoids and organoids co-cultured with fibroblasts and leukocytes.
    [Nature Protocols]

    Abstract

    Bcl6 Controls Meningeal Th17–B Cell Interaction in Murine Neuroinflammation

    Investigators performed in-depth characterization of meningeal versus parenchymal T helper 17 cell-induced rodent neuroinflammation. The most pronounced cellular and transcriptional differences between these compartments was the localization of B cells exhibiting a follicular phenotype exclusively to the meninges.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    NAD+ Supplementation Reduces Neuroinflammation and Cell Senescence in a Transgenic Mouse Model of Alzheimer’s Disease via cGAS–STING

    Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages

    The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for extracellular-signal-regulated kinases 1/2 (Erk1/2) in Toll-like receptor pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.
    [Cell Reports]

    Full ArticleGraphical Abstract
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    REVIEWS

    Autophagy in Metabolic Disease and Aging

    Scientists summarize the role of autophagy in the pathogenesis of metabolic diseases associated with or occurring in the context of aging, including insulin resistance, type 2 diabetes mellitus and sarcopenic obesity, and describes its potential as a therapeutic target.
    [Nature Reviews Endocrinology]

    Abstract

    Tumor-Draining Lymph Nodes: At the Crossroads of Metastasis and Immunity

    The authors discuss current understanding of the early mechanisms through which tumors engage lymphatic transport and condition tumor-draining lymph nodes, the significance of these changes for both metastasis and immunity, and potential implications of the tumor-draining lymph node for immunotherapy.
    [Science Immunology]

    Abstract

    Enteric Neuroimmune Interactions Coordinate Intestinal Responses in Health and Disease

    Investigators discuss how the enteric nervous system can regulate and be regulated by immune responses and how such interactions control whole tissue physiology.
    [Mucosal Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Sanofi Provides Update on Phase III Study Evaluating Rilzabrutinib for the Treatment of Pemphigus

    The Phase III PEGASUS trial evaluating rilzabrutinib to treat pemphigus, a rare autoimmune skin condition, did not meet its primary or key secondary endpoints. Rilzabrutinib’s safety profile remained consistent with previous results and no new safety signals were identified.
    [Sanofi]

    Press Release

    NIH Providing $185 Million for Research to Advance Understanding of How Human Genome Functions

    The National Institutes of Health is providing approximately $185 million over five years to the Impact of Genomic Variation on Function (IGVF) consortium, initiated and funded by NIH’s National Human Genome Research Institute. IGVF consortium investigators will work to understand how genomic variation alters human genome function, and how such variation influences human health and disease.
    [National Human Genome Research Insitute]

    Press Release
    FEATURED EVENT

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    October 13 – 14, 2021
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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Innate Immune Regulation

    Herman B Wells Center for Pediatric Research – Indianapolis, Indiana, United States

    Research Technician – Autoimmune Diseases

    Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States

    Research Assistant – GI Research Institute

    GI Research Institute – Vancouver, British Columbia, Canada

    Postdoctoral Scholar – Immunology of Lungs

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Faculty Position – Translational Immunology

    University of Miami – Miami, Florida, United States

    > See All Jobs

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