 | | Vol. 13.35 – 17 September, 2021 |
| |
|
|
| Researchers showed that low-density lipoprotein receptor-related protein 1 mediated cell surface binding and the endocytosis of serum amyloid A-retinol complexes in cultured cells.
[Science] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators reported that a bifunctional fusion protein that simultaneously inhibited TGF-β and PD-L1, bintrafusp alfa, effectively synergized with radiotherapy, leading to superior survival in multiple therapy-resistant murine tumor models with poor immune infiltration.
[Cancer Cell] |
|
|
|
| Ex vivo treatment of mouse and human dendritic cells promoted their IFN1-dependent activation, and vaccination studies in mice demonstrated stimulation of antigen cross-presentation and T cell priming in vivo.
[Science Translational Medicine] |
|
|
|
| Serotonin enhanced expression of PD-L1 on mouse and human cancer cells in vitro via serotonylation, which is the formation of covalent bonds between glutamine residues and serotonin, resulting in activation of small G proteins.
[Science Translational Medicine] |
|
|
|
| Investigators found high expression of RORα in liver-resident NK cells/ILC1s. Mice with conditional ablation of Rora in LrNK cells/ILC1s and conventional NK (cNK) cells had decreased LrNK cells/ILC1s but normal numbers of cNK cells.
[Hepatology] |
|
|
|
| Using LysMCre-mediated mammalian STE20-like protein kinase 1/2 (Mst1/2)-deficient mice, researchers found that MST1 deficiency exacerbated cardiac dysfunction after myocardial infarction.
[Circulation Research] |
|
|
|
| The authors reported that high-salt diet induced natural killer cell–mediated tumor immunity by inhibiting PD-1 expression while enhancing IFNγ and serum hippurate.
[Science Advances] |
|
|
|
| Researchers demonstrated a chemical approach, termed “switchable” immune modulator, to limit the systemic exposure and therefore ameliorate their toxicities.
[Science Advances] |
|
|
|
| Investigators combined radiation, immunotherapies, genetic mouse models, and antibody depletion experiments to identify the role of NK cells in overcoming resistance to radiation therapy in orthotopic models of head and neck squamous cell carcinoma
[Clinical Cancer Research] |
|
|
|
| Olfr78 functioned together with Gpr132 to mediate lactate-induced generation of protumoral M2-tumor-associated macrophages. Syngeneic Olfr78-deficient mice exhibited reduced tumor progression and metastasis together with an increased anti- versus protumoral immune cell population.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Scientists showed that in atopic dermatitis, IL-4 and IL-13 stimulated the expression of 3β-hydroxysteroid dehydrogenase 1, a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Researchers reported that serine/arginine splicing factor 1 (SRSF1) intrinsically regulated invariant natural killer T cell development by directly targeting Myb and balancing the abundance of short and long isoforms.
[Cellular & Molecular Immunology] |
|  |
|
|
|
| The authors present a roadmap that defines important next steps needed to overcome conceptual and methodological challenges, opportunities for future interdisciplinary research, and suggestions for translating promising mechanistic studies into therapeutic interventions.
[Nature Reviews Neurology] |
|
|
|
| Mechanistically, investigators found that grancalcin binds to the plexin-b2 receptor and partially inactivated its downstream signaling pathways, thus repressing osteogenesis and promoting adipogenesis of bone marrow mesenchymal stromal cells.
[Cell Metabolism] |
|
|
|
| Scientists focus on the role of miRNAs in the regulation of B cell receptor signaling as it pertains to B lymphocyte development and function.
[Immunological Reviews] |
|
|
|
|
| More than 7 million Canadians suffer from immune-mediated inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, and related conditions. The COVID-19 Immunity Task Force and Vaccine Surveillance Reference Group will supporting a nationwide study that will assess COVID-19 vaccine effectiveness, safety and vaccine hesitancy in this potentially vulnerable group of people.
[COVID-19 Immunity Task Force] |
|
|
|
| The Sjögren’s Foundation has awarded a total of $200,000 to four US research projects focused on identifying diagnostic biomarkers and improving treatment of Sjögren’s syndrome. The foundation’s Research Grants Program “places a high priority on both clinical and basic scientific research into the cause, prevention, detection, treatment, and cure for Sjögren’s, with opportunities open to both junior and senior-level investigators,” the foundation stated when announcing the grant recipients.
[Sjogren’s Syndrome News] |
|
|
|
|
| October 19 – 22, 2021
Aarhus, Denmark |
|
|
|
|
|
| Scripps Research Florida – Jupiter, Florida, United States |
|
|
|
| Karolinska Institutet – Stockholm, Sweden |
|
|
|
| | Herman B Wells Center for Pediatric Research – Indianapolis, Indiana, United States |
|
|
|
| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
|
|
|
| GI Research Institute – Vancouver, British Columbia, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
