 | | Vol. 13.37 – 8 October, 2021 |
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| Researchers examined how targeting pathways that inhibit the differentiation of inflammatory myeloid cells affect antitumor immunity.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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 | | Scientists demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.
[Science Advances] |
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| Investigators described a DNA-based assembly that tubulated lysosomes in macrophages without activating them. Proteolytic activity maps at single-lysosome resolution revealed that tubular lysosomes were less degradative and showed proximal to distal luminal pH and Ca2+ gradients.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors demonstrated a trigger of thymic regeneration, centered on detecting the loss of dying thymocytes that were abundant during steady-state T cell development.
[Cell Reports] |
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| Programmed death ligand 1 (PD-L1) expression in human ovarian cancer cells after PARP inhibitors treatment was examined by western blotting and flow cytometry.
[Journal of Translational Medicine] |
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| Irbesartan suppressedmonocyte chemoattractant protein-1 (MCP-1) production and the accumulation of Ly6C+CCR2+ monocytes and fibrocytes in the inflamed colon, downregulated the expression of type 1 collagen and matrix metalloproteinase 9 and inhibited the development of intestinal fibrosis and tumors.
[Scientific Reports] |
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| The objective of this study was to identify genomic regions with a biological relevance for the immunocompetence of piglets. Genome-wide Association Studies in 535 Landrace and 461 Large White piglets were performed, investigating 20 immune relevant traits.
[BMC Genomics] |
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| Researchers investigated the IL-12 inducibility of fermented foods using the specific antibody. Fermented soybean foods such as Tempeh and Natto are attracting attention in terms of nutrition, functionality, and food problems.
[Journal of Food Biochemistry] |
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| Scientists used poly (lactic-co-glycolide) to co-encapsulate type 1 diabetes-relevant antigen and three distinct TREG-inducing molecules – rapamycin, all-trans retinoic acid, and butyrate – that targeted the mechanistic target of Rapa, the retinoid pathway, and histone deacetylase inhibition, respectively.
[Drug Delivery and Translational Research] |
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| Investigators determined the effect of intrauterine administration of mouse PBMCs prior to embryo implantation on endometrial receptivity and embryo implantation, and examined the underlying mechanism of Treg/Th17 cell balance following intrauterine administration of PBMCs.
[Journal of Reproduction and Development] |
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| Scientists discuss the existing and emerging therapies that target mast cells, and they consider how these treatments can help us to understand mast cell functions in disease.
[Nature Reviews Immunology] |
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| The authors provide an overview of the major immune cell populations that reside in the peritoneal cavity and highlight their contribution to the initiation, progression, or resolution of peritoneal diseases.
[Journal of Leukocyte Biology] |
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| X4 Pharmaceuticals, Inc. announced that it has completed enrollment in the ongoing pivotal Phase II clinical trial of its lead candidate, mavorixafor, in the treatment of patients with genetically confirmed warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene.
[X4 Pharmaceuticals, Inc.] |
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| Revelation Biosciences, Inc. announced it has been granted ethics committee approval in Australia to conduct a Phase Ib allergen challenge clinical study to evaluate the potential utility of REVTx-99 for treating patients with allergic rhinitis and patients with chronic nasal congestion.
[Revelation Biosciences, Inc.] |
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| October 27 – 29, 2021
Virtual |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Imperial College London – London, England, United Kingdom |
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