Immune Regulation News Volume 13.38 | Oct 15 2021

    By
    Justin.choi
    -
    0
    88






    2021-10-15 | IRN 13.38


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.38 – 15 October, 2021
    TOP STORY

    The Cholesterol Metabolite 25-Hydroxycholesterol Restrains the Transcriptional Regulator SREBP2 and Limits Intestinal IgA Plasma Cell Differentiation

    Researchers examined how the cholesterol metabolite 25-hydroxycholesterol (25-HC) impacted the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase, the enzyme generating 25-HC, had higher frequencies of immunoglobulin A-secreting antigen-specific B cells upon immunization or infection.
    [Immunity]

    AbstractGraphical Abstract

    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    IL-33-Induced Metabolic Reprogramming Controls the Differentiation of Alternatively Activated Macrophages and the Resolution of Inflammation

    Scientists showed that uncoupling protein-2-mediated mitochondrial reprogramming and the transcription factor GATA3 specifically controlled the differentiation of pro-resolving alternatively activated macrophages in response to the alarmin IL-33.
    [Immunity]

    AbstractGraphical Abstract

    Dynamic Changes in tRNA Modifications and Abundance during T Cell Activation

    Investigators examined the transfer RNA (tRNA) and mRNA pools of T cells during their vigorous proliferation and differentiation upon triggering their antigen receptor.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    PI3Kδ Coordinates Transcriptional, Chromatin, and Metabolic Changes to Promote Effector CD8+ T Cells at the Expense of Central Memory

    Using patient samples and a mouse model, the authors demonstrated that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibited exaggerated features of effector populations both in vitro and after viral infection that was associated with increased Fas-mediated apoptosis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Proinflammatory Cytokines Promote TET2-Mediated DNA Demethylation during CD8 T Cell Effector Differentiation

    To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, scientists explored the role of interleukin-12 in the imprinting of IFNg expression during CD8 T cell priming.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Alloantigen-Activated (AAA) CD4+ T Cells Reinvigorate Host Endogenous T Cell Immunity to Eliminate Pre-Established Tumors in Mice

    Alloantigen-activated CD4+ T cells were generated from CD4+ T cells isolated from BALB/c mice in cultures with dendritic cells induced from C57BL/6 mice.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Adoptive CD8+ T Cell Grafted with Liposomal Immunotherapy Drugs to Counteract the Immune Suppressive Tumor Microenvironment and Enhance Therapy for Melanoma

    The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. Effector OT-1 CD8+ T cells conjugated with liposomal immune regulators were developed to address this issue.
    [Nanoscale]

    AbstractGraphical Abstract

    RSV Infection-Elicited High MMP-12–Producing Macrophages Exacerbate Allergic Airway Inflammation with Neutrophil Infiltration

    Investigators showed that respiratory syncytial virus (RSV)-induced alveolar macrophages, which produced high levels of matrix metalloproteinase-12, exacerbated allergic airway inflammation with increased neutrophil infiltration.
    [iScience]

    Full ArticleGraphical Abstract

    Estrogen Deprivation Induces Chemokine Production and Immune Cell Recruitment in In Vitro and In Vivo Models of Estrogen Receptor-Positive Breast Cancer

    Researchers investigated the effect of estrogen deprivation on the expression of chemokines and immune infiltration in vitro and in an ER+ immunocompetent mouse model.
    [Breast Cancer Research]

    Full Article

    Explore tools and resources for your return to the lab
    REVIEWS

    Tumor Burden and Efficacy of Immune-Checkpoint Inhibitors

    The authors summarize evidence supporting the utility of tumor burden as a biomarker to guide the use of immune-checkpoint inhibitors.
    [Nature Reviews Clinical Oncology]

    Abstract

    INDUSTRY AND POLICY NEWS

    MoonLake Immunotherapeutics AG and Helix Acquisition Corp. Announce Business Combination Agreement to Create Publicly Listed Biotechnology Company Advancing Tri-specific Nanobody® Sonelokimab

    MoonLake Immunotherapeutics AG and Helix Acquisition Corp. announced they have entered into a definitive business combination agreement.
    [MoonLake Immunotherapeutics AG]

    Press Release

    Chinchilla Supplier Loses License over Animal Welfare Violations

    Moulton Chinchilla Ranch, the main US source of the animals for research, had a years-long history of disturbing findings in United States Department of Agriculture inspections.
    [The Scientist LLC]

    Press Release

    FEATURED EVENT

    Cell Symposium: Overcoming Therapy Resistance in Cancer

    November 8 – 10, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Immunology & Stem Cell Engineering

    Hong Kong University – Hong Kong, China

    Postdoctoral Position – Translational Oncology

    Medical University of Vienna – Vienna, Austria

    Postdoctoral Fellow – Inflammatory Bowel Diseases

    Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States

    Assistant Professor – Cancer Research

    University of Manitoba – Winnipeg, Manitoba, Canada

    Doctoral Researcher – Immunology

    Helmholtz Centre for Infection Research – Braunschweig, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immune Regulation News Twitter