 | | Vol. 13.41 – 5 November, 2021 |
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| To better understand the molecular properties of senescent cells (SNCs), the authors identified key determinants of SNC identity by screening for genes nearby senescence-associated super-enhancers conserved across stressors, cell types, and mammalian species.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used an orthotopic non–small cell lung cancer mouse model to study immune checkpoint blockade-refractory CD8+ T cell responses.
[Science Immunology] |
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| Investigators described an additional pathway of thymic self-antigens acquisition that enabled circulating antigenic macromolecules to access both murine and human thymi.
[Nature Communications] |
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| The authors found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody treatment.
[Bone Research] |
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| In three murine models, CD8+ cells bearing resident memory T cells markers remained in previously inflamed joints during remission.
[Cell Reports] |
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| A light-triggered disassembly of nanoplatform co-loaded an aggregation induced emission photosensitizer and paclitaxel was prepared for on-command drug release and synergistic chemo-photodynamic therapy.
[Journal of Nanobiotechnology] |
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| The percentage of Tregs in the spleen, blood, and brain was detected using flow cytometry, and the number of Tregs in the ischemic hemisphere was counted using transgenic mice with an enhanced green fluorescent protein‐tagged Foxp3.
[Journal of the American Heart Association] |
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| Scientists discovered that lipopolysaccharide clearance through liver sinusoidal endothelial cells involved endocytosis and lysosomal inactivation via Stabilin-1 and 2 but did not involve TLR4.
[iScience] |
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| Investigators established and verified an in vitro experimental system for the direct co-culture of cell pellets prepared from mouse auricular chondrocytes and macrophages polarized into four phenotypes.
[Scientific Reports] |
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| Scientists discuss how the risk factors for Alzheimer’s disease (AD), particularly Apolipoprotein E, Aβ, α-secretase, β-secretase, γ-secretase, Tau, and neuroinflammation, modulate T cell activation and the association between T cells and pathological AD hallmarks.
[Aging Cell] |
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| Investigators present various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, promoting the tissue integration and soft and hard tissue regeneration potential of the administered biomaterial.
[Journal of Tissue Engineering] |
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| Medigus Ltd. announced that Polyrizon Ltd., informed Medigus that its pre-clinical data demonstrated a potential to prevent allergic reactions induced by house dust mites and Timothy grass pollen allergens, and may also prevent respiratory tract allergy reactions caused by other allergens.
[Medigus Ltd. (GlobeNewswire, Inc.)] |
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| Prokarium, a biopharmaceutical company pioneering the oncology field of microbial immunotherapy, announced the appointment of Livija Deban, PhD, as Chief Scientific Officer.
[Prokarium] |
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| November 14 – 20, 2021
Virtual |
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| | Ohio University – Columbus, Ohio, United States |
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| | Malmö, Sweden – Lund University |
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| | Calgary, Alberta, Canada – University of Calgary |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Duke University – Durham, North Carolina, United States |
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