Immune Regulation News Volume 13.45 | Dec 3 2021

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    Justin.choi
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    2021-12-03 | IRN 13.45


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.45 – 3 December, 2021
    TOP STORY

    Antigen-Presenting Innate Lymphoid Cells Orchestrate Neuroinflammation

    Investigators defined a population of inflammatory group 3 innate lymphoid cells that infiltrate the central nervous system in a mouse model of multiple sclerosis.
    [Nature]

    AbstractPress Release

    Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Microbial Regulation of Hexokinase 2 Links Mitochondrial Metabolism and Cell Death in Colitis

    The authors examined the microbial regulation of hexokinase 2 and its impact on inflammation using mice lacking hexokinase 2 in intestinal epithelial cells.
    [Cell Metabolism]

    AbstractGraphical Abstract

    Biomaterials Direct Functional B Cell Response in a Material-Specific Manner

    To probe the role of B cells in biomaterial scaffold response, scientists evaluated the B cell response to biomaterial materials implanted in a muscle wound using a biological extracellular matrix as a reference for a naturally derived material, and synthetic polyester polycaprolactone as a reference for a synthetic material.
    [Science Advances]

    Full Article

    Anlotinib Induces a T Cell-Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD1 Checkpoint Blockade in Neuroblastoma

    Researchers proved that anlotinib facilitated tumor vessel normalization at least partially through CD4+ T cells, reprogrammed the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME, significantly inhibited tumor growth and effectively prevented systemic immunosuppression.
    [Clinical Cancer Research]

    AbstractFull Article

    Peripheral Tolerance by Treg via Constraining OX40 Signal in Autoreactive T Cells against Desmoglein 3, a Target Antigen in Pemphigus

    Scientists used desmoglein 3, a pemphigus antigen expressed in keratinocytes, to analyze peripheral tolerance under physiological antigen-expression conditions.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity

    An epigenetic CRISPR-Cas9 screen of 1,218 chromatin regulators identified TRIM28 as a suppressor of PD-L1 expression.
    [Cancer Immunology Research]

    Abstract

    Meteorin-β/Meteorin Like/IL-41 Attenuates Airway Inflammation in House Dust Mite-Induced Allergic Asthma

    Increased Metrnβ effectively blocked the development of airway hyperreactivity and decreased inflammatory cell airway infiltration and type 2 cytokine production, which was associated with downregulated dendritic cell-mediated adaptive immune responses.
    [Cellular & Molecular Immunology]

    Abstract

    Histone Deacetylase 3 Represses Cholesterol Efflux during CD4+ T-cell Activation

    After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate. The authors showed that histone deacetylase 3 was critical for activation of murine peripheral CD4+ T cells.
    [eLife]

    Full Article

    3D In Vitro M2 Macrophage Model to Mimic Modulation of Tissue Repair

    To establish a well-defined 3D cell culture model to mimic the tissue repair process, researchers utilized THP-1 human monocytic cells and a 3D collagen matrix as a biomimetic tissue model.
    [NPJ Regenerative Medicine]

    Full Article

    Sequence and Vector Shapes Vaccine Induced Antibody Effector Functions in HIV Vaccine Trials

    Investigators compared vaccine responses in Phase I and II studies in humans utilizing various combinations of DNA/vector, vector/vector and DNA/protein HIV vaccines.
    [PLoS Pathogens]

    Full Article

    Sequential Modulation of the Wnt/β-Catenin Signaling Pathway Enhances Tumor-Intrinsic MHC I Expression and Tumor Clearance

    Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence.
    [Gynecological Oncology]

    Abstract
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Putative Regulation of Macrophage-Mediated Inflammation by Catestatin

    Scientists hypothesize that macrophages produce catestatin in an inflammation-dependent manner and thereby might self-regulate inflammation in an autocrine fashion.
    [Trends in Immunology]

    Abstract

    Resident and Migratory Adipose Immune Cells Control Systemic Metabolism and Thermogenesis

    The authors review the key findings that have shaped the understanding of how immune cells regulate adipose tissue homeostasis to control organismal metabolism.
    [Cellular & Molecular Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Selecta Biosciences and Sobi Announce Completion of Enrollment in DISSOLVE Phase III Study Evaluating SEL-212 for Chronic Refractory Gout

    Selecta Biosciences, Inc. and Swedish Orphan Biovitrum AB announced the completion of enrollment for DISSOLVE I, the first of two clinical studies of the Phase III DISSOLVE development program of SEL-212 for chronic refractory gout.
    [Selecta Biosciences, Inc.]

    Press Release

    BeiGene and EUSA Pharma Announce NMPA Approval of SYLVANT® (Siltuximab for Injection) in China for Idiopathic Multicentric Castleman Disease

    BeiGene, Ltd. and EUSA Pharma, Ltd. announced that the China National Medical Products Administration has approved SYLVANT® for the treatment of adult patients with multicentric Castleman disease who are HIV negative and human herpes virus-8 negative,.
    [BeiGene, Ltd.)]

    Press Release
    FEATURED EVENT

    Immunometabolism at the Crossroads of Obesity and Cancer

    January 16 – 20, 2022
    Banff, Alberta, Canada

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    JOB OPPORTUNITIES

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    Fred Hutch – Seattle, Washington, United States

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    Allen Institute – Seattle, Washington, United States

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    University Medical Center Freiburg – Freiburg, Germany

    PhD Positions – Cell Surface Glycome

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Research Fellow – Bioinformatics

    The University of British Columbia – Vancouver, British Columbia, Canada

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