Immune Regulation News Volume 14.08 | Mar 4 2022

May 12, 2022

2022-03-04 | IRN 14.08

Immune Regulation News by STEMCELL Technologies

Vol. 14.08 – 4 March, 2022

TOP STORY

CD8⁺ T Cells and Fatty Acids Orchestrate Tumor Ferroptosis and Immunity via ACSL4

Mechanistically, interferon γ stimulated ACSL4 and altered tumor cell lipid pattern, thereby increasing incorporations of arachidonic acid into C16 and C18 acyl chain-containing phospholipids.
[Cancer Cell]

Abstract Graphical Abstract

Register for the Neuro-immune Interactions In The Central Nervous System.

PUBLICATIONSRanked by the impact factor of the journal

Dedifferentiation-Associated Inflammatory Factors of Long-Term Expanded Human Hepatocytes Exacerbate Their Elimination by Macrophages during Liver Engraftment

Scientists found that accompanying with dedifferentiation, long-term cultured proliferating human hepatocytes upregulated a panel of chemokines and cytokines related to innate immunity, which were referred as dedifferentiation-associated inflammatory factors.
[Hepatology]

Abstract

Dedifferentiation-Associated Inflammatory Factors of Long-Term Expanded Human Hepatocytes Exacerbate Their Elimination by Macrophages during Liver Engraftment

Researchers found that accompanying with dedifferentiation, long-term cultured ProliHH upregulated a panel of chemokines and cytokines related to innate immunity, which were referred as dedifferentiation-associated inflammatory factors.
[Hepatology]

Abstract

The Inhibitory Coreceptor CD22 Restores B Cell Signaling by Developmentally Regulating Cd45^−/− Immunodeficient B Cells

In their investigation of how B cell antigen receptor signaling was restored in Cd45^−/− cells, scientists found that the coreceptor CD22 switched from an inhibitory to a stimulatory function in these cells.
[Science Signaling]

Abstract

Phosphorylation of Serine-893 in CARD11 Suppresses the Formation and Activity of the CARD11-BCL10-MALT1 Complex in T and B Cells

Investigators demonstrated that PKCθ/β-dependent CARD11 phosphorylation also suppressed CARD11 functions in T or B cells.
[Science Signaling]

Full Article

Single-Cell Analysis of Skin Immune Cells Reveals an Angptl4-ifi20b Axis That Regulates Monocyte Differentiation during Wound Healing

The authors performed flow cytometry and single-cell RNA sequencing to examine the immune cell landscape of excisional wounds from Angptl4^+/+ and Angptl4^−/− mice.
[Cell Death & Disease]

Full Article

Liver Environment–Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells

Researchers developed a protocol to generate stable numbers of liver-located CD8 T cells, and used intravital microscopy to record movement patterns of CD8 T cells in livers of live mice.
[Journal of Immunology]

Abstract

Dominant Negative TGF-β Receptor Type II in T Lymphocytes Promotes Anti-tumor Immunity by Modulating T Cell Subsets and Enhancing CTL Responses

Investigators demonstrated that dominant negative TGF-β receptor type II specifically targeting T cells decreased tumor load in tumor-bearing mice.
[Biomedicine & Pharmacotherapy]

Full Article Graphical Abstract

In Vitro and In Vivo Functions of T Cells Produced in Complemented Thymi of Chimeric Mice Generated by Blastocyst Complementation

Scientists generated thymus-complemented chimeric mice, assessed the efficacy of anti-PD-L1 antibody in tumor-bearing chimeric mice, and then investigated T cell function.
[Scientific Reports]

Full Article

REVIEWS

Post-Translational Modification of MALT1 and Its Role in B Cell- and T Cell-Related Diseases

Investigators summarize recent progress in relevant studies regarding the physiological and pathophysiological functions of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), post-translational modifications of MALT1, and its role in B cell- and T cell-related diseases.
[Biochemical Pharmacology]

Abstract Graphical Abstract

Drug Allergy and Autoimmune Diseases

Few studies have examined in detail the relationship between drug eruptions, a major symptom of drug allergy, and systemic autoimmune diseases, and their actual status remains unclear.
[Allergology International]

Full Article

INDUSTRY AND POLICY NEWS

Nationwide Study Led By U Of U Health Tests New Treatment For “Brain On Fire” Disease

University of Utah (U of U) Health researchers will lead a five-year, $22-million nationwide clinical trial for NMDA receptor encephalitis –– a type of autoimmune encephalitis that prompts the immune system to mistakenly attack the brain.
[University of Utah]

Press Release

$10 Million NIH Grant Funds Research on Treatments for Autoimmune Diseases

The University of Rochester Medical Center was recently funded to join a prestigious network of academic and clinical researchers, the National Institutes of Health (NIH) Accelerating Medicines Partnership^®: Autoimmune and Immune-Mediated Diseases program.
[University of Rochester]

Press Release

FEATURED EVENT

CD8⁺ T Cells and Fatty Acids Orchestrate Tumor Ferroptosis and Immunity via ACSL4

Dedifferentiation-Associated Inflammatory Factors of Long-Term Expanded Human Hepatocytes Exacerbate Their Elimination by Macrophages during Liver Engraftment

Dedifferentiation-Associated Inflammatory Factors of Long-Term Expanded Human Hepatocytes Exacerbate Their Elimination by Macrophages during Liver Engraftment

The Inhibitory Coreceptor CD22 Restores B Cell Signaling by Developmentally Regulating Cd45^−/− Immunodeficient B Cells

Phosphorylation of Serine-893 in CARD11 Suppresses the Formation and Activity of the CARD11-BCL10-MALT1 Complex in T and B Cells

Single-Cell Analysis of Skin Immune Cells Reveals an Angptl4-ifi20b Axis That Regulates Monocyte Differentiation during Wound Healing

Liver Environment–Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells

Dominant Negative TGF-β Receptor Type II in T Lymphocytes Promotes Anti-tumor Immunity by Modulating T Cell Subsets and Enhancing CTL Responses

In Vitro and In Vivo Functions of T Cells Produced in Complemented Thymi of Chimeric Mice Generated by Blastocyst Complementation

Post-Translational Modification of MALT1 and Its Role in B Cell- and T Cell-Related Diseases

Drug Allergy and Autoimmune Diseases

Nationwide Study Led By U Of U Health Tests New Treatment For “Brain On Fire” Disease

$10 Million NIH Grant Funds Research on Treatments for Autoimmune Diseases

EMBO: Stroke-Immunology

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Research Fellow – Cancer Metabolism and Tumour Immunology

PhD Scientist – Oncology

Postdoctoral Scientist – Liver Resident Memory T Cell

Postdoctoral Positions – Human Immunology and Inflammation

Senior Scientist – Inflammatory and Autoimmune Disorders

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