 | | Vol. 14.13 – 8 April, 2022 |
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| Scientists identified transcriptionally distinct exhausted T cell subpopulations, mapped their differentiation trajectories via transitory cellular states toward exhausted CD8+ T cells, and localized these cell states to specific splenic niches.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a genetic-tracing approach, termed the DivisionRecorder, that reported the extent of past proliferation of cell pools in vivo.
[Nature Immunology] |
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| The authors unveiled a novel mechanism of the endogenous cannabinoid system-mediated suppression on T cell immunity against cancer, and suggested that cannabis and cannabinoid drugs should be avoided during immunotherapy.
[Signal Transduction and Targeted Therapy] |
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Inhibition of CXCL12/CXCR4 axis with AMD3100 or conditional knockout of CXCR4 attenuated osteogenic precursor cells migration and subsequent pathological new bone formation in animal models of ankylosing spondylitis.
[Science Advances] |
| | Scientists demonstrated that pathogen recognition by the Dectin-1a isoform resulted in the formation of a stable receptor fragment devoid of the ligand binding domain.
[Nature Communications] |
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| Using a loss-of-function lipid accumulation screening, investigators identified ubiquitin-specific peptidase 9 X-linked (USP9X) as a factor that suppressed lipid uptake in macrophages.
[Journal of Clinical Investigation] |
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| The authors identified TNF-α and S100A8/A9 proteins as key regulators that controlled the inflammatory osteoclast precursor response during chronic inflammation.
[Bone Research] |
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| Researchers demonstrated that mouse MDSCs expressed functional Hv1 proton channels by immunofluorescence microscopy, flow cytometry, and Western blot, besides performing a biophysical characterization of its macroscopic currents via patch-clamp technique.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists used induced pluripotent stem cell (iPSC) technology to investigate whether murine mucosal-associated invariant T (MAIT) cells functioned as tumor-promoting or inhibitory cells. MAIT cells were reprogrammed into iPSCs and redifferentiated towards MAIT-like cells.
[eLife] |
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| The authors observed the downregulation of senescence-related genes by adoptive infusion of NK cells in 26 cases in peripheral blood CD3+ T cells.
[Cell Death & Disease] |
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| Researchers demonstrated that mice with intestinal epithelium-specific deletion of Krüppel-like factor 5 (Klf5) developed Th17-dependent colonic inflammation.
[JCI Insight] |
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| Investigators demonstrated that IP3R-mediated Ca2+ signaling and calcineurin regulated B cell proliferation and survival by activating metabolic reprogramming in response to B cell receptor stimulation.
[iScience] |
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| IL-37 isoform D transgene amplified ST2+ immune cells, promoted M2 macrophage polarization and type 2 cytokine secretion in white adipose tissue that mediated beiging and inflammation resolution, thereby increasing energy expenditure, and reducing obesity and insulin resistance in high-fat diet-fed mice.
[Cell Death Discovery] |
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| The authors review the phenotypic heterogeneity of intratumoral B cells and the importance of tertiary lymphoid structures (TLS) in their generation as well as the potential of B cells and TLS as prognostic and predictive biomarkers.
[Nature Reviews Clinical Oncology] |
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| Drawing insights from autoimmunity, scientists review the molecular phenotypes, architectural contexts, antigen specificities, effector mechanisms and regulatory pathways relevant to tumor-infiltrating B lymphocytes in human cancer.
[Nature Reviews Cancer] |
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| The authors review both antitumor and tolerogenic dendritic cell (DC) responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs.
[Science Immunology] |
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| Twist Bioscience Corporation and MediSix Therapeutics announced a collaboration to discover novel antibodies against five undisclosed targets. Twist will leverage its proprietary Library of Libraries to discover five novel antibodies directed against MediSix’s targets.
[Twist Bioscience Corporation] |
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| Shenzhen Pregene Biopharma and CellPoint announced an exclusive license agreement for the development and commercialization of PRG-1801, Pregene’s single domain antibody-based anti-BCMA chimeric antigen receptor (CAR) T cell program, for the treatment of hematological indications.
[Shenzhen Pregene Biopharma Co. Ltd (Cision US, Inc.)] |
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| May 6 – 10, 2022
Portland, Oregon, United States |
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| | Luxembourg Institute of Health – Luxembourg, Luxembourg |
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| | Columbia University Medical Center – New York, New York, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | University of Kentucky – Lexington, Kentucky, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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