 | | Vol. 14.36 – 7 October, 2022 |
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| In mouse models of pancreatic cancer, scientists provide in vivo genetic evidence that TGFβ receptor type 2 signaling in healthy dermatopontin+ universal fibroblasts is essential for the development of cancer-associated LRRC15+ myofibroblasts.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Chemotaxis of obese asthma and healthy-weight asthma TH cells, and their adhesion to obese and healthy-weight non-asthmatic airway smooth muscle, was investigated.
[American Journal of Respiratory and Critical Care Medicine] |
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| Researchers reported that the specified delivery of vitamin C at the tumor site by responsive lipid nanoparticles could efficiently induce oxidative toxicity and the polarization of M1 macrophages, promoting the infiltration of activating cytotoxic T lymphocytes in the tumor microenvironment.
[ACS Nano] |
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| Investigators showed that T cell receptor signaling in Treg cells induced the nuclear translocation of serine/threonine kinase 4 (Stk4), leading to the formation of an Stk4–NF-κB p65–Foxp3 complex that regulated Foxp3- and p65-dependent transcriptional programs.
[Science Immunology] |
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| Using a CXCR4 R334X gain-of-function mouse model of WHIM syndrome, scientists showed that lymphopoiesis is reduced because of a dysregulated mesenchymal stem cell transcriptome characterized by a switch from an adipogenic to an osteolineage-prone program with limited lymphopoietic activity.
[Science Immunology] |
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| The authors assessed a fusion protein with extracellular domain of high affinity IgE receptor, FcεRIα, linked to a IgD/IgG4 hybrid Fc domain we term IgETRAP, to reduce the risk of IgG1 Fc-mediated side effects.
[Nature Communications] |
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| While the immature colon of C. rodentium-infected germ-free mice did not allow sufficient extravasation of neutrophils into the gut lumen, colonization with OMM12 + MC2 commensals initiated the expansion and activation of the visceral vascular system enabling granulocyte transmigration.
[Microbiome] |
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| Researchers used tumor microenvironment responsive nanogels with tumor-targeting capability by Panc02 cell membranes coating and inhibition of tumor-derived prostaglandin E2, aimed at improving natural killer cells activation, and inducing activated NK cells-dependent dendritic cells recruitment.
[Small] |
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| Investigators showed that in the syngeneic subcutaneous KPC Pancreatic cancer tumor model, exhausted CD8+ T cells were localized in the tumor, and that chemophototherapy is enhanced in combination with immune checkpoint blockade.
[APL Bioengineering] |
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| Researchers found that Furin, a member of the subtilisin/kexin-like PCs family, was highly expressed in thymic epithelial cells compared with other members of this family.
[iScience] |
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| Scientists investigated whether CX-5461 could inhibit the development of imiquimod-induced experimental psoriasis in mice.
[Experimental Dermatology] |
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| The authors detail the complexity of differential lipid metabolism in distinct subtypes of T cells that drive the antitumor or pro-tumor immunity in specific tumor microenvironment states.
[Lipids in Health and Disease] |
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| Kezar Life Sciences, Inc. announced that it has received clearance of its Investigational New Drug (IND) application from the FDA for zetomipzomib, its first-in-class, selective immunoproteasome inhibitor, for the treatment of autoimmune hepatitis.
[Kezar Life Sciences, Inc.] |
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| The University of Pennsylvania announced that it had received a $50 million gift from Stewart and Judy Colton, which will be used to further develop the work of Penn’s Colton Center for Autoimmunity at the Perelman School of Medicine.
[Forbes] |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Aarhus University – Aarhus C, Denmark |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Alia Therapeutics – Trento, Italy |
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| | University of Miami – Miami, Florida, United States |
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