 | | Vol. 14.29 – 12 August, 2022 |
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| Investigators found that terminally exhausted T cells had unexpected chromatin features that limit their transcriptional potential.
[Science Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By generating new knockout mouse strains lacking CD2 or CD48 in the C57BL/6 background, scientists determined that whereas CD2 was necessary on T cells for T cell activation, its ligand CD48 was not required on antigen-presenting cells.
[Science Immunology] |
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| The authors reported that lncRNA-GM polarized T helper 17 differentiation but inhibited iTreg differentiation by reducing activity of Foxo1, a transcriptional factor thatwas important in inhibiting TH17 differentiation but promoting Treg generation.
[Science Advances] |
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| Marker regions were located in genes with a described function for innate lymphoid cells (ILCs) , such as Tbx21, Gata3, or Il23r, but also in genes that have not been related to ILC biology.
[Journal of Experimental Medicine] |
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| Researchers showed that the adaptive immune system played a vital role in the antitumor effect of pharmacologic inhibition of Myc.
[Cellular & Molecular Immunology] |
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| Investigators found that CDCP1 was present on both human and mouse retinal pigmented epithelial cells, a component of the blood-retina barrier, using a new anti-CDCP1 monoclonal antibody that they developed.
[JCI Insight] |
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| The authors examined the contact hypersensitivity (CHS) response and NET formation in Il36rn−/− mice. Il36rn−/− mice showed enhanced CHS responses, increased infiltration of inflammatory cells, including neutrophils, CD4+ T cells, and CD8+ T cells.
[Scientific Reports] |
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| Scientists performed whole-genome bisulfite sequencing to assess DNA methylation patterns in nine pig immune cell populations: CD21+ and CD21− B cells, four T cell fractions, natural killer and myeloid cells, and neutrophils.
[BMC Genomics] |
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| Researchers investigated the apoptosis rate of Tregs and their suppressive activity in patients with SLE and then to recognize the genes and signaling pathways that cause Treg apoptosis.
[Lupus] |
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| Investigators summarises the latest understanding of CD20+ T cells, their presence in various diseases, their putative function and how they may be an ongoing target of CD20-depleting agents.
[Inflammation Research] |
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| A decision by the Southwest National Primate Research Center to retain its director with full duties despite a finding that he engaged in research misconduct has sparked disbelief.
[ScienceInsider] |
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| September 12 – 14, 2022
Liverpool, England, United Kingdom |
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| | Duke University – Durham, North Carolina, United States |
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| | Columbia University – New York, New York, United States |
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| | Essen University Hospital – Essen, Germany |
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| | King’s College London – London, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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