Immune Regulation News Volume 14.30 | Aug 19 2022

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    2022-08-19 | IRN 14.30


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.30 – 19 August, 2022
    TOP STORY

    MYB Orchestrates T Cell Exhaustion and Response to Checkpoint Inhibition

    The authors showed that the long-term proliferative potential, multipotency, and repopulation capacity of exhausted T (Tpexcells during chronic infection are selectively preserved in a small population of transcriptionally distinct CD62L+ TPEX cells.
    [Nature]

    Full Article
    Science is demanding. That's why scientists work smart.
    PUBLICATIONSRanked by the impact factor of the journal

    Carbon Source Availability Drives Nutrient Utilization in CD8+ T Cells

    CD8+ T cells responding to Listeria infection preferentially consumed lactate over glucose as a TCA cycle substrate in vitro, with lactate enhancing T cell bioenergetic and biosynthetic capacity.
    [Cell Metabolism]

    Full ArticlePress ReleaseGraphical Abstract

    Signatures of Recent Activation Identify a Circulating T Cell Compartment Containing Tumor-Specific Antigen Receptors with High Avidity

    Researchers investigated the fate and functionality of tumor neoantigen–specific T cells with T cell receptors of distinct avidities in a well-established, reductionist preclinical tumor model and human patients with melanoma.
    [Science Immunology]

    Abstract

    TGF-β Promotes Stem-Like T Cells via Enforcing Their Lymphoid Tissue Retention

    The authors demonstrated that TGF-β was essential for the optimal maintenance of stem-like CD8+ T cells and inhibited their differentiation into migratory effectors during chronic viral infection.
    [Journal of Experimental Medicine]

    Abstract

    Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis

    Inhibition of melanoma cell-T-cell immunoglobulin and mucin domain 3 (Tim-3) promoted tumor growth in both immunocompetent and immunocompromised mice, while melanoma-specific Tim-3 overexpression attenuated tumorigenesis.
    [Cancer Research]

    Abstract

    Checkpoint Blockade–Induced Dermatitis and Colitis Are Dominated by Tissue Resident Memory T Cells and Th1/Tc1 Cytokines

    Investigators reported their analysis of tissues from patients with immune-related adverse events dermatitis using multiparameter immunofluorescence, spatial transcriptomics, and RNA in situ hybridization.
    [Cancer Immunology Research]

    Abstract

    TOX Deficiency Facilitates the Differentiation of IL-17A-Producing γδ T Cells to Drive Autoimmune Hepatitis

    Scientists reported that dual-stage loss of TOX in thymocytes hierarchically impaired medullary thymic epithelial cells maturation, promoted thymic IL-17A-producing γδ T-cell lineage commitment, and led to the development of fatal autoimmune hepatitis via different mechanisms.
    [Cellular & Molecular Immunology]

    Abstract

    A Novel Dibenzofuran from Endophytic Fungus Mycosphaerella nawae Preferentially Inhibits CD4+ T Cell Activation and Proliferation

    The immune activities of isomycousnine enamine were first evaluated on the proliferation and cytokines production of T and B cells by using MTT and ELISA methods, respectively.
    [Journal of Applied Microbiology]

    Abstract

    Identification lncRNA Expression Profiles in Pediatric Localized Scleroderma

    Researchers investigated the profiling of inflammatory cells in skin samples from pediatric localized scleroderma. Among them, CD4+ T cells was up-regulated.
    [Journal of Cosmetic Dermatology]

    Abstract
    Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.
    REVIEWS

    The Evolving Role of Tissue-Resident Memory T Cells in Infections and Cancer

    Investigators provide a concise review of the development and physiological role of CD8+ resident memory T cells, their involvement in diseases, and their potential therapeutic exploitation.
    [Science Advances]

    Full Article

    Regulatory T Cell Therapy Approaches

    Scientists review the current landscape of regulatory T cell therapy, considering emergent approaches and technologies presenting novel ways to engage Tregs.
    [Clinical & Experimental Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    NIH Awards Feinstein Institutes $3.8M to Study Radiation Exposure, Sepsis

    Scientists from The Feinstein Institutes for Medical Research have been awarded a five-year, $3.8 million grant from the National Institutes of Health (NIH) to study how radiation affects the human body’s immune system and how to better treat sepsis in people who have been exposed to radiation injury.
    [Feinstein Institutes for Medical Research]

    Press Release

    Q32 Bio and Horizon Therapeutics Announce Collaboration in Autoimmune Diseases

    Q32 Bio and Horizon Therapeutics plc announced that they have entered into a collaboration and option agreement to develop ADX-914 for the treatment of autoimmune diseases.
    [Q32 Bio]

    Press Release
    FEATURED EVENT

    Preclinical and Personalized Breast Cancer Research: Preclinical Models Course

    October 10 – 12, 2022
    Lausanne, Switzerland

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    JOB OPPORTUNITIES

    Postdoctoral Position – Lung Cancer

    NYU Langone Health – New York, New York, United States

    Postdoctoral Scholar – Cancer TCR Gene Therapy

    The University of Chicago – Chicago, Illinois, United States

    Research Associates – Center for Perioperative Organ Protection

    Duke University – Durham, North Carolina, United States

    Staff Associate – Dependencies in Esophageal and Gastric Cancer

    Columbia University – New York, New York, United States

    Postdoctoral Researcher – Immuno-Oncology

    Essen University Hospital – Essen, Germany

    > See All Jobs

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