 | | Vol. 14.38 – 28 October, 2022 |
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| Researchers described an integrated systems approach, combining publicly available databases, zebrafish chemical screens, machine learning, and mouse preclinical models to identify environmental factors that control intestinal inflammation.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified CD40-induced genes in classical type 1 dendritic cells, including Cd70, Tnfsf9, Ptgs2 and Bcl2l1, and examined their contributions to anti-tumor immunity.
[Nature Immunology] |
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| Susd2−/− effector CD8+ T cells showed enhanced production of antitumor molecules, which consequently blunted tumor growth in multiple syngeneic mouse tumor models.
[Nature Immunology] |
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| The authors reported the design of tetraspecific molecules engaging natural killer cell-activating receptors NKp46 and CD16a, the β-chain of the interleukin-2 receptor, and a tumor-associated antigen.
[Cell Reports Medicine] |
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| Investigators identified cross-reactivity between rheumatoid arthritis-relevant autoantigens and bacterial taxa in the closely related families Lachnospiraceae and Ruminococcaceae.
[Science Translational Medicine] |
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| Scientists designed a homology-directed repair gene editing strategy that inserted the CTLA-4 cDNA into the first intron of the CTLA-4 genomic locus in primary human T cells.
[Science Translational Medicine] |
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| Investigators prepared a penetrating macrophage-based nanoformulation-encapsulating hydrogel that responded to the periodontitis microenvironment.
[ACS Nano] |
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| The authors found a redundant and critical role for the zinc finger protein 36 (ZFP36) proteins in regulating T cell quiescence.
[Science Immunology] |
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| Invariant natural killer T (iNKT) cells in the thymus were divided into three subpopulations by the expression of the natural killer cell receptor CD244 and the chemokine receptor CXCR6 and designated as C0, C1, or C2 iNKT cells.
[Science Immunology] |
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| Mechanisms of enhanced anti-tumor immunity were investigated using scRNA-seq, multiplex image analysis and flow cytometry of the tumor immune infiltrate. In both treatment models, anti-VISTA upregulated stimulated antigen-presentation pathways and reduced myeloid mediated suppression.
[Cancer Immunology Research] |
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| Ferroptosis was identified to play a role in necrotizing enterocolitis (NEC) using bioinformatics analyses and wet experiments. Inhibition of ferroptosis significantly alleviated NEC in newborn mice.
[iScience] |
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| The authors evaluated the effects of co-overexpressing beta interferon and Leukemia inhibitory factor in human adipose-derived stem cells on the experimental autoimmune encephalomyelitis.
[Scientific Reports] |
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| Severe combined immunodeficient mice received human carbonic anhydrase I, keyhole limpet hemocyanin, or phosphate-buffered saline orally for seven days.
[Scientific Reports] |
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| Scientists assess the roles of CD4+ T cells in the center of inflammaging especially in rheumatoid arthritis and emphasize arthritogenic effector functions of senescent T cell.
[Inflammation Research] |
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| Q32 Bio and Horizon Therapeutics plc announced that the first patient has been dosed in a randomized, double-blind, placebo-controlled, Phase II multi-center proof-of-concept study in adult subjects to evaluate the safety and efficacy of ADX-914 in persistent, moderate-to-severe atopic dermati.
[Q32 Bio] |
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| Intrommune Therapeutics, Inc. announced the completion of enrollment in the Phase I OMEGA Clinical Study for patients with peanut allergy. The Phase I OMEGA Clinical Trial will be a 48-week trial, including up to 34 weeks of maintenance therapy, in peanut allergic adults.
[Intrommune Therapeutics, Inc. (GlobeNewswire, Inc.)] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | King’s College London – London, England, United Kingdom |
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| | Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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