 | | Vol. 14.39 – 4 November, 2022 |
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| Researchers reported the generation of a mouse model based on the neuromedin U receptor 1 promoter as a driver for simultaneous expression of Cre recombinase and green fluorescent protein, which enabled gene targeting in group 2 innate lymphoid cells without affecting other innate and adaptive immune cells.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists generated a new genetic tool to target group 2 innate lymphoid cells for depletion or gene deletion in the presence of an intact adaptive immune system.
[Nature] |
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| The authors demonstrated that Ncor1/2 deletion limited B cell differentiation via impaired recombination, attenuated pre-BCR signaling and enhanced STAT5-dependent transcription.
[Nature Immunology] |
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| Using a genetic timestamping system in mice, investigators showed that persistent plasma cells accrued in bone marrow at an approximately constant rate of one cell per hour over a period spanning several weeks after a single immunization with a model antigen.
[Science Immunology] |
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| Activities of dendritic cells that present tumor antigens are often suppressed in tumors. Scientists reported that this suppression was induced by tumor microenvironment-derived factors, which activated the activating transcription factor-3 transcription factor and downregulated cholesterol 25-hydroxylase.
[Nature Communications] |
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| Researchers showed that Mcam identified inflammatory brain endothelial cells with pro-migratory transcriptomic signature during experimental autoimmune encephalomyelitis.
[Brain] |
| | Investigators developed a novel adeno-associated virus neoantigen vaccine, modified with TLR9 inhibitory fragments, PD-1 trap, and PD-L1 miRNA, which extended the persistence of meAAV and activate neoantigen-specific T cell responses in immune-competent colorectal and breast cancer murine models.
[Cancer Immunology Research] |
| | To overcome PD-1/PD-L1 inhibition in dendritic cells, the authors developed a novel adeno-associated virus neoantigen vaccine, modified with TLR9 inhibitory fragments, PD-1 trap, and PD-L1 miRNA, which extended the persistence of meAAV and activate neoantigen-specific T cell responses in immune-competent colorectal and breast cancer murine models.
[Cancer Immunology Research] |
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| Scientists verified the polarization and activation of OH2 in RAW264.7 cells in vitro. Subsequently, they evaluated the antitumour ability of OH2 and anti-SIRPα combined therapy in a tumour-bearing mouse model.
[BMC Medicine] |
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| An allergic rhiniti (AR) mouse model was developed using ovalbumin as the specific antigen. The AR response was assessed in mice after treatment with allergen-specific immunotherapy or/and TAFA4.
[NPJ Vaccines] |
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| Investigators found that loss of Latexin (LXN) promoted macrophage M2 polarization and PD-L2 expression in macrophage, thus, inhibited the function of T cells.
[Cell Death Discovery] |
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| The effects of extracellular ATP on MC activation induced by MrgprB2, the mouse ortholog of human Mas-relate G protein-coupled receptor X2 (MRGPRX2), were examined in mouse peritoneal mast cells.
[Scientific Reports] |
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| Investigators explored how metabolism regulates lymphocytes beyond the classical T cell subsets, with a focus on on the innate lymphoid cell family.
[Journal of Experimental Medicine] |
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| The University of Arizona Health Sciences Center for Advanced Molecular and Immunological Therapies, or CAMI, received a strong vote of support from Arizona Governor Doug Ducey, who designated $150 million in new funding for the Phoenix-based center.
[The University of Arizona] |
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| The inaugural cohort of Chan Zuckerberg Science Initiative Diversity Leadership Awards has been announced, to be given outstanding early- and mid-career scientists “who through their outreach, mentoring, and teaching—have a record of promoting diversity, equity and inclusion in their scientific fields.”
[Forbes] |
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| January 22 – 25, 2022
Santa Fe, New Mexico, United States |
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| | Université Libre de Bruxelles – Gosselies, Belgium |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | University of North Carolina – Chapel Hill, North Carolina, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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