 | | Vol. 14.40 – 18 November, 2022 |
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| Using single-cell RNA and T cell receptor sequencing of cardiac immune infiltrates from Pdcd1–/–MCtla4+/– mice, the authors identified clonal effector CD8+ T cells as the dominant cell population.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| When orally administered, a probiotic-inspired nanomedicine adhered strongly to the mucus layer and restored intestinal redox balance and immune regulation homeostasis in a murine model of acute colitis induced by dextran sodium sulfate.
[Advanced Materials] |
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| Intestinal epithelial cells receptor-interacting protein kinase (RIPK3) cooperates with RIPK1 to trigger MLKL-independent production of T cell-recruiting chemokines and MHC class II molecules which amplify and sustain alloreactive T cell responses.
[Blood] |
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| Investigators found that circulating memory T cells were dispensable for anamnestic protection from Candida albicans skin infection, and tissue-resident memory cell–mediated protection from C. albicans reinfection required IL–3.
[Science Immunology] |
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| Using confocal intravital microscopy, investigators observed directed abluminal neutrophil motility along pericyte processes towards perivascular mast cells, a response that created neutrophil extravasation hotspots.
[Nature Communications] |
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| Scientists found αCTLA-4 drove increased inflammation and colonic tissue damage in mice with genetic predisposition to intestinal inflammation, acute gastrointestinal infection, transplantation with a dysbiotic fecal microbiome, or dextran sodium sulfate administration.
[Journal of Experimental Medicine] |
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| Researchers explored the contribution of the lipid kinase PIK3C3/VPS34 to the generation of positively selecting peptides in thymic epithelial cells.
[Autophagy] |
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| Investigators examined whether sputum migration inhibitory factor protein correlated with clinical and molecular characteristics of severe neutrophilic asthma in the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes cohort.
[Thorax] |
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| Scientists showed the development of myocarditis in A/J mice induced by anti-PD-1 monoclonal antibody administration alone without tumor cell inoculation, immunization, or viral infection.
[Cell Reports] |
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| The authors identified a differential time-dependent reliance of activating T cells on the synthesis versus uptake of various non-essential amino acids, which they corroborated with functional assays.
[Cell Reports] |
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| Researchers had identified that a probiotic strain (Lactobacillus casei) derived siderophore (ferrichrome) efficiently reprogramed tumor-associated macrophages and increased CD8+ T cell infiltration into tumors that paralleled a marked reduction in tumor burden in a syngeneic mouse model of pancreatic cancer.
[Communications Biology] |
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| Using CD4+ T cells lacking Zfp36 and Zfp36l1, scientists combined the quantification of mRNA transcription, stability, abundance and translation with crosslinking immunoprecipitation and metabolic profiling to determine how they regulate T cell metabolism and differentiation.
[Scientific Reports] |
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| Tumor necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies.
[Nature Reviews Immunology] |
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| Horizon Therapeutics plc announced that it has entered a multi-year scientific collaboration with Johns Hopkins University School of Medicine to identify new disease targets and develop therapies for patients with serious autoimmune and inflammatory conditions.
[Horizon Therapeutics plc] |
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| In recognition of their ongoing research and leadership in rheumatology, The Feinstein Institutes for Medical Research’s Betty Diamond, MD, and Anne Davidson, MBBS, have been awarded top honors by the American College of Rheumatology and the Association of Rheumatology Professionals.
[The Feinstein Institutes] |
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| February 13 – 16, 2023
Breckenridge, Colorado, United States |
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| | Institut Curie – Paris, France |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Toronto Mississauga – Mississauga, Ontario, Canada |
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| | Université Libre de Bruxelles – Gosselies, Belgium |
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| | Queen Mary University of London – London, England, United Kingdom |
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