 | | Vol. 14.41 – 25 November, 2022 |
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| The effect of cholesterol 25-hydroxylase on atherosclerosis progression was analyzed by bone marrow adoptive transfer of cells from wild-type or Ch25h–/– mice to lethally irradiated Ldlr–/– mice, followed by a Western diet feeding for 12 weeks.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In-depth phenotyping of peripheral blood T cells, including c-Met+ T cells, was undertaken in groups of patients with inflammatory and noninflammatory cardiomyopathies, patients with noncardiac autoimmunity, and healthy controls.
[Circulation] |
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| Eosinophils infiltration and chemotaxis were investigated in peripheral blood and lung tissues from pulmonary arterial hypertension patients without allergic history and sugen/hypoxia-induced pulmonary hypertension mice.
[European Respiratory Journal] |
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| To determine the therapeutic potential of inhibiting B cell function in pulmonary fibrosis, scientists examined the effects of anti-CD20 B cell ablation therapy to selectively remove mature B cells from the immune system and inhibit bleomycin-induced lung fibrosis.
[European Respiratory Journal] |
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| Researchers found that a small population of medullary thymic epithelial cells expressed the coinhibitory receptor cytotoxic T lymphocyte-associated protein 4 (CTLA-4) . These CTLA-4+ cells were detectable in perinates, peaked around young adulthood and expanded sixfold in the absence of Aire.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists developed a single-cell framework to simultaneously immuno-phenotype circulating, endovascular, and tissue-resident cells at the maternal-fetal interface throughout gestation, discriminating maternal and fetal contributions.
[Cell Reports] |
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| Investigators determined the effect of human umbilical cord-derived mesenchymal stem cells on asthmatic lungs by modulating innate immune cells and effector T cells using a murine asthmatic model.
[Molecular and Cellular Biology] |
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| In a carcinogen-induced mouse oral squamous cell carcinoma model, interleukin-23 receptor expression on Tregs and Treg function were determined by flow cytometry.
[Immunity Inflammation and Disease] |
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| Using Gene Expression Profiling Interactive Analysis and Tumor Immune Estimation Resource, data obtained from The Cancer Genome Atlas were analyzed, and the results showed that ZDHHC9 was highly expressed in colon cancer and that patients with higher ZDHHC9 expression levels had a worse prognosis.
[Oncology Letters] |
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| The authors review the differentiation, regulation, variety, and function of resident memory T cells and the roles they play in skin diseases, including cutaneous melanoma and psoriasis.
[Clinical Immunology] |
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| The FDA approved teplizumab, the first drug with the ability to change the course of type 1 diabetes, or any autoimmune disease. Yale School of Medicine played a crucial role in the drug’s trials, most of which were led by Dr. Kevan Herold, Long Professor of Immunobiology and of Medicine
[Yale School of Medicine.] |
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| January 29 – February 2, 2023
Banff, Alberta, Canada |
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| | University of Kent – Canterbury, England, United Kingdom |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Institut Curie – Paris, France |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Toronto Mississauga – Mississauga, Ontario, Canada |
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