 | | Vol. 14.43 – 9 December, 2022 |
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| Mouse genetic and organoid co-culture experiments demonstrated that a CD206+ subset of intestinal macrophages secreted Wnt ligands, which maintained the mesenchymal niche cells important for Paneth cell differentiation.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In Treg cells, a CRISPR-Cas9–enabled Pfkp deletion recapitulated the metabolism of Camk4−/− Treg cells, and improved their function and stability in vitro and in vivo.
[Science Advances] |
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| KLF4-expressing CD8 T cells in exhaustion contexts showed the features of transitory effector CD8 T cells. Enforced KLF4 expression increased CD8 T cell differentiation into transitory effector subsets and enhanced their antitumor immunity.
[Science Advances] |
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| CD1a is a virtually monomorphic major histocompatibility complex class I-like molecule, highly expressed by skin and mucosal Langerhans cells, and presents lipid antigens to T-cells. Researchers showed an important role for CD1a in linking cutaneous and systemic inflammation in two experimental models.
[Nature Communications] |
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| The conserved cell population was abundant in the human and murine colon, and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis.
[Nature Communications] |
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| Setd2, a histone H3K36 methyltransferase, supported GATA3+ST2+ intestinal thymic-derived Treg (tTreg) cells by facilitating the expression and reciprocal relationship of GATA3 and ST2 in tTreg cells.
[Nature Communications] |
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| Using single-cell RNA sequencing and flow cytommetry, investigators showed that lung Vγ4+ and Vγ6+ cells from tumor-free and tumor-bearing mice expressed contrasting cell surface molecules as well as distinct co-inhibitory molecules.
[Journal of Experimental Medicine] |
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| In orthotopic transplantation experiments, scientists observed increased infiltration of T cells and prolonged survival in immunocompetent mice transplanted with cancer cells with reduced expression of gal 4.
[Cancer Immunology Research] |
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| Mechanistically, GABA enhanced succinate-flavin adenine dinucleotide-lysine specific demethylase1 signaling to regulate histone demethylation of Bcl2l11 and Dusp2.
[Cell Reports] |
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| The authors provide insights into current studies of the T cell receptors repertoire in graft-versus-host disease, and potential future clinical implications of T cell receptor sequencing.
[Bone Marrow Transplantation] |
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| Biopharma Akeso Inc. has announced it will enter into a collaboration potentially worth up to $5 billion with Summit Therapeutics Inc., by out-licensing its breakthrough bispecific antibody, ivonescimab for development and commercialisation in the US, Canada, Europe, and Japan.
[European Pharmaceutical Review] |
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| February 9 – 12, 2023
Cancun, Mexico |
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| | The Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | VIB-UAntwerp – Antwerp, Belgium |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Lund University – Lund, Sweden |
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