 | | Vol. 14.44 – 16 December, 2022 |
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| Investigators expressed in normal mice mutated ZAP-70 molecules with different affinities for the CD3 chains, or wild-type ZAP-70 at graded expression levels under tetracycline-inducible control.
[Journal Of Experimental Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed greater T cell responses when mice were immunized in the middle of their rest versus their active phase.
[Nature Communications] |
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| The conserved cell population was abundant in the human and murine colon, and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis.
[Nature Communications] |
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| The authors elucidated the immunological aspect of Parkinson’s disease by employing a wide range of cellular assays, immunocytochemistry, and flow cytometry to examine CD4+ T cells.
[Npj Parkinsons Disease] |
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| Scientists reported that Fe-doped and doxorubicin loaded HA@Cu2−XS-PEG nanomaterials were rationally designed as targeted Fe-PHCN@DOX nano-nuclear-reactors, which evoked persistent T cell immune response together with anti-PD-L1 nanobodies.
[Journal Of Nanobiotechnology] |
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| The authors investigated whether fibroblastic reticular cells in lymph nodes could induce tolerogenic macrophage generation and further influence T cell immunity at an early stage of allogeneic hematopoietic stem cell transplantation.
[Transplantation] |
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| Male BALB/c mice were used as experimental objects to explore the effect of L-theanine on heat stress-induced changes in immune function and its mechanism. Three doses of L-theanine were used: low, medium, and high.
[Food & Function] |
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| Investigators defined a critical role of epiregulin-EGFR signaling between dendritic cells and fibroblasts to maintain elevated ECM production and accumulation in fibrotic tissue.
[Science Immunology] |
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| The authors investigated how maternal chronic inflammation affected the T cell immune development from the fetal to the neonatal period and how offspring responded to postnatal IL-1β challenge when exposed to an adverse intrauterine environment.
[American Journal Of Reproductive Immunology] |
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| Scientists review the progress in an emerging adaptation of CRISPR technologies to advance our fundamental immunological knowledge and identify novel disease targets for immunotherapy of infection, inflammation, and cancer.
[Nature Reviews Immunology] |
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| The authors review recently described immunologic mechanisms that drive breach of tolerance, chronic synovitis, and remission.
[Immunity] |
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| Genprex, Inc. has struck an exclusive license agreement with the University of Pittsburgh for a worldwide, exclusive license to some patent applications and a worldwide, non-exclusive license to use certain related know-how, all related to modulating autoimmunity in Type 1 diabetes by using gene therapy.
[Proactive North America Inc.,] |
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| Associate Professor Michael Gantier has been funded $1,496,654.00 for his project on the therapeutic targeting of TLR7 in autoimmunity.
[Monash University] |
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| February 19 – 22, 2023
Banff, Alberta, Canada |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States |
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| | Westlake University – Hangzhou, China |
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| | Flanders Institute for Biotechnology – Leuven, Belgium |
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| | The Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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