 | | Vol. 15.04 – 3 February, 2023 |
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| The authors showed in multiple specific pathogen-free, gnotobiotic, and germ-free murine models of gastrointestinal (GI) GVHD that the initiation of the intestinal damage by the pathogenic T cells altered ambient oxygen levels in the GI tract and caused dysbiosis.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified oxidative phosphorylation as the highest discriminating process among macrophages in tissues from different organs in homeostasis by analysis of RNA-seq data in both humans and mice.
[Immunity] |
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| Investigators undertook molecular and functional studies to interrogate the significance of neutrophil CC1 signaling in mouse and human orthotopic liver transplantation recipients.
[Journal Of Clinical Investigation] |
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| Combining anti-TNF and anti–IL-6 antibodies in collagen-induced arthritis mouse models resulted in sustained long-term remission, improved histology, and effects on bone remodeling pathways.
[Science Translational Medicine] |
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| Researchers investigated the fate of ALDH1A3-positive β-cells during pair-feeding by lineage-tracing, somatically ablated ALDH1A3 in diabetic β-cells, and used a novel selective ALDH1A3 inhibitor to treat diabetes.
[Nature Communications] |
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| After the in-situ cryo-immune engineering treatment, the ratio of the CD8+ cytotoxic T cells to the immunosuppressive regulatory T cells was increased by more than 100 times, in not only the primary tumors with cryosurgery, but also distant tumors without freezing.
[Nature Communications] |
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| The authors reported that the expression and secretion of procathepsin-L was induced by serum amyloid A in innate immune cells, contributing to its late and systemic accumulation in experimental and clinical sepsis.
[Science Advances] |
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| Investigators reported that hypoxia-induced factor 1α was the master transcription factor for Il10 in retinoid-related orphan receptor gamma (RORγt+) Tregs.
[Science Advances] |
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| Scientists reported that IL-33-mediated ILC2 activation promoted the Th2 cell response to papain; however, the Th2 cell response to ovalbumin/alum immunization was thymic stromal lymphopoietin dependent, but independent of ILC2s.
[Cell Reports] |
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| Investigators summarize the evidence showing that activated platelets have an active role in the pathogenesis and the progression of immune-mediated inflammatory diseases.
[Nature Reviews Immunology] |
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| The authors discuss how cancer cell-intrinsic features, including (epi)genetic aberrations, signaling pathway deregulation and altered metabolism, play a key role in orchestrating the composition and functional state of the immune landscape, and influence the therapeutic benefit of immunomodulatory strategies.
[Nature Reviews Cancer] |
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| Scientists discuss the functions of ADAR1 and ZBP1 in regulating innate immune responses in development and disease.
[Trends In Immunology] |
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| KEYTRUDA® plus chemotherapy significantly improved progression-free survival versus standard of care chemotherapy alone, as first-line treatment for patients with stage III-IV or recurrent endometrial carcinoma, regardless of mismatch repair status.
[Merck] |
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| April 23 – 26, 2023
Paris, France |
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| | Beckman Research Institute – Monrovia, California, United States |
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| | Karolinksa Institutet – Solna, Sweden |
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| | Imperial College London – London, England, United Kingdom |
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| | The University of Luxembourg – Belval, Luxembourg |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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