 | | Vol. 15.06 – 17 February, 2023 |
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| Investigators identified a population of innate lymphocytes that they termed tissue-resident memory-like natural killer cells.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists revealed a second positive selection pathway in germinal center B cells (GCBCs), documented rewired IL-21 receptor (IL-21R signaling) in GCBCs, and linked specific TFH– and Ag-derived signals to GCBC differentiation.
[Science Immunology] |
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| Researchers demonstrated that the follicular helper T (TFH) cell effector cytokine interleukin-21 (IL-21) joined B cell receptor and CD40 in supporting BGC selection, and revealed that strong IL-21 signaling prioritized antibody-secreting cell differentiation in vivo.
[Science Immunology] |
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| Scientists identified an immunoglobulin-like receptor called Signaling Lymphocyte Activation Molecular Family-7 (SLAMF7), as a key suppressor of inflammation during sepsis, and found that the expression of SLAMF7 on monocytes/macrophages was significantly elevated in patients with sepsis and septic mice.
[Journal Of Clinical Investigation] |
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| Palmitoyl protein transferase 1 inhibition induced lysosomal lipid peroxidation, which led to lysosomal membrane permeabilization and cell death that could be reversed by the antioxidant N-acetylcysteine, but not by other lipid peroxidation antioxidants.
[Journal Of Clinical Investigation] |
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| The authors investigated a β-cyclodextrin nanoparticle formulation, encapsulating the Toll-like receptor 7 and 8 agonist R848, to reprogram myeloid cells in the glioma microenvironment.
[Nature Communications] |
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| Investigators developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen to stimulate production of interleukin-4 and other type 2-associated cytokines, without negative infection-related sequelae.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers demonstrated that resistance to type 1 diabetes in non-obese diabetic mice was due to the absence of Drak2 in T cells, and required the presence of Tregs.
[Cell Reports] |
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| Scientists found that periostin deficiency significantly decreased the infiltration of PD-1+ tumor-associated macrophages in colorectal cancer tissues.
[Cell Reports] |
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| Investigators review possible disease mechanisms underlying triggers that are associated with the loss of immune tolerance with consequent recognition of self-antigens; these triggers include infections, tumours and immune-checkpoint inhibitor therapies.
[Nature Reviews Neurology] |
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| The authors review what is known about the T cell response in autoimmunity and cancer, and highlight ways in which we can learn from the nexus of these two diseases to improve the application, efficacy, and management of immunotherapies.
[Immunity] |
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| For his work developing an individually tailored, cell-specific approach to treating cancer by combining drug treatments with immune-response therapeutics, Aleksandar Obradovic is the grand prize winner of the 2023 Michelson Philanthropies & Science Prize for Immunology.
[AAAS] |
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| March 5 – 9, 2023
Banff, Alberta, Canada |
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| | Twincore GmbH – Hannover, Germany |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Beckman Research Institute – Monrovia, California, United States |
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| | The University of Luxembourg – Belval, Luxembourg |
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