Immune Regulation News Volume 15.07 | Feb 24 2023

    By
    Laurisa Dohm
    -
    0
    71








    2023-02-24 | IRN 15.07


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.07 – 24 February, 2023
    TOP STORY

    The Gut Microbiota Promotes Distal Tissue Regeneration via RORγ+ Regulatory T Cell Emissaries

    Scientists discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gut sites, notably acutely injured skeletal muscle and fatty liver.
    [Immunity]

    AbstractGraphical Abstract
    Learn more about the Frontiers in Immunology scientific symposium, April 11th &12.
    PUBLICATIONSRanked by the impact factor of the journal

    Monocytes Re-Enter the Bone Marrow during Fasting and Alter the Host Response to Infection

    The authors identified a fasting-induced switch in leukocyte migration that prolonged monocyte lifespan and altered susceptibility to disease in mice, and showed that fasting during the active phase induced the rapid return of monocytes from the blood to the bone marrow.
    [Immunity]

    AbstractGraphical Abstract

    I-Ag7 β56/57 Polymorphisms Regulate Non-Cognate Negative Selection to CD4+ T Cell Orchestrators of Type 1 Diabetes

    Using a nonobese diabetic mouse model, investigators showed that heterozygous expression of the type 1 diabetes-protective allele I-Ag7 β56/57 induced negative selection to the I-Ag7-restricted T cell repertoire, including beta-islet-specific CD4+ T cells.
    [Nature Immunology]

    Full Article

    Immunosuppressive Reprogramming of Neutrophils by Lung Mesenchymal Cells Promotes Breast Cancer Metastasis

    Using mouse models of metastatic breast cancer in the lungs, scientists showed that, although neutrophils isolated from bone marrow or blood were minimally immunosuppressive, lung-infiltrating neutrophils were robustly suppressive of both T cells and natural killer cells.
    [Science Immunology]

    Full ArticlePress Release

    Adipocyte Autophagy Limits Gut Inflammation by Controlling Oxylipin and IL-10

    Researchers found that upon intestinal inflammation, visceral adipocytes upregulatef autophagy and that adipocyte-specific loss of the autophagy gene Atg7 exacerbated inflammation.
    [Embo Journal]

    Full ArticleGraphical Abstract

    Liver X Receptor Controls Follicular Helper T Cell Differentiation via Repression of TCF-1

    Scientists demonstrated that liver X receptor (LXR), an oxysterol sensor previously known to integrate metabolic and inflammatory signaling, acted as a critical negative regulator of Tfh cell differentiation.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Type III Interferon Drives Thymic B Cell Activation and Regulatory T Cell Generation

    By comparing thymic B cells to activated Peyer’s patch B cells at steady state, the authors found that thymic B cell activation started during the neonatal period and was characterized by TCR/CD40-dependent activation, followed by immunoglobulin class switch recombination, without forming germinal centers.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Maternal γδ T Cells Shape Offspring Pulmonary Type 2 Immunity in a Microbiota-Dependent Manner

    Investigators’ unraveled a maternal γδ T cell-microbiota-short-chain fatty acids axis that regulated neonatal lung immunity.
    [Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    Platelet-Instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4-Dependent Manner

    Investigators discovered a population of profibrotic macrophages marked by expression of Spp1, Fn1, and Arg1 —termed Spp1 macrophages — which expanded after organ injury.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Start Fast. Finish Faster. Streamline your assays with purified human primary cells from STEMCELL Technologies. View products now.
    REVIEWS

    The Extracellular Matrix and the Immune System: A Mutually Dependent Relationship

    The extracellular matrix, long considered an inert scaffold, can now be seen as a highly dynamic partner to the immune system. The authors aim to highlight the absolute interdependence of these systems with consequences for therapy.
    [Science]

    AbstractGraphical Abstract

    NETworking with Cancer: The Bidirectional Interplay between Cancer and Neutrophil Extracellular Traps

    Scientists discuss the bidirectional interplay by which cancer stimulates neutrophil extracellular trap (NET) formation, and NETs in turn support disease progression.
    [Cancer Cell]

    Abstract
    INDUSTRY AND POLICY NEWS

    Treasury Takes Back £1.6Bn Promised for Science

    The money had been earmarked for UK involvement in the EU’s Horizon Europe €100bn research programme.The funds have not been spent because the UK’s association with the programme has been held up by the dispute over the Northern Ireland Protocol.
    [BBC News]

    Press Release

    FDA to Require Diversity Plan for Clinical Trials

    The FDA will soon require researchers and companies seeking approval for late-stage clinical trials to submit a plan for ensuring diversity among trial participants.
    [Nature News]

    Full Article
    FEATURED EVENT

    Myeloid Cells: Development, Diversity and Distinct Biological Roles

    April 16 – 19, 2023
    Snowbird, Utah, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Officer – Bioinformatics

    The University of Melbourne – Melbourne, Australia

    PhD Studentship – Cancer Biology and Stromal Immunology

    University College London – London, England, United Kingdom

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Research Fellow – Molecular and Cellular Biology

    The University of Melbourne – Melbourne, Australia

    Senior Research Associate – Early Cancer Institute

    University of Cambridge – Cambridge, England, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immune Regulation News Twitter