Immune Regulation News Volume 15.08 | Mar 3 2023

    By
    Laurisa Dohm
    -
    0
    91








    2023-03-03 | IRN 15.08


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.08 – 3 March, 2023
    TOP STORY

    Apoptotic Cell Fragments Locally Activate Tingible Body Macrophages in the Germinal Center

    The authors showed by multiple redundant and complementary methods that tingible body macrophages derived from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor that was prepositioned in the lymphoid follicle.
    [Cell]

    Full ArticleGraphical AbstractPress Release
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    PUBLICATIONSRanked by the impact factor of the journal

    Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T Cell-Secreted Cytokines

    Investigators performed a genome-scale screen to discover alternative pathways for T cell-mediated killing of MHC class I deficient tumor cells, and carried out further mechanistic studies demonstrating that inhibition of autophagy amplified pro-apoptotic effects of cytokines in tumor cells.
    [Cancer Discovery]

    Abstract

    T Cell Egress via Lymphatic Vessels Is Tuned by Antigen Encounter and Limits Tumor Control

    Researchers investigated whether lymphatic vessel-mediated effector CD8+ T cell egress limited the accumulation of a broad repertoire of functional CD8+ T cells.
    [Nature Immunology]

    Full ArticlePress Release

    Dampening Type 2 Properties of Group 2 Innate Lymphoid Cells by a Gammaherpesvirus Infection Reprograms Alveolar Macrophages

    Using murid herpesvirus 4, a mouse gammaherpesvirus, scientists showed that after infection, lung-resident and recruited group 2 innate lymphoid cells exhibited a reduced ability to expand and produce type 2 cytokines in response to house dust mites, thereby contributing to protection against asthma.
    [Science Immunology]

    Abstract

    Itaconate Ameliorates Autoimmunity by Modulating T Cell Imbalance via Metabolic and Epigenetic Reprogramming

    Mechanistically, itaconate suppressed glycolysis and oxidative phosphorylation in T helper 17- and Treg-polarizing T cells.
    [Nature Communications]

    Full Article

    AP-1–Independent NFAT Signaling Maintains Follicular T Cell Function in Infection and Autoimmunity

    Using lupus-prone mice, researchers demonstrated that genetic disruption or pharmacologic inhibition of NFAT signaling specifically impacted follicular helper T cell maintenance and lead to amelioration of autoantibody production and renal injury.
    [Journal Of Experimental Medicine]

    Abstract

    IL-10-Providing B Cells Govern Pro-Inflammatory Activity of Macrophages and Microglia in CNS Autoimmunity

    Depleting B cells via anti-CD20 in a mouse model of multiple sclerosis unleashed the activity of myeloid cells and microglia and accelerated disease severity, while adoptive transfer of IL-10-providing B cells restored in vivo control of central nervous system macrophages and microglia.
    [Acta Neuropathologica]

    Full Article

    Delay Modulates the Immune Response to Nerve Repair

    Researchers investigated the activation of remodeling pathways within the macrophage population when peripheral nerve injury repair was delayed, and identified alteration of key upstream regulators of the inflammatory response.
    [Npj Regenerative Medicine]

    Full Article

    Pericyte Stem Cells Induce Ly6G+ Cell Accumulation and Immunotherapy Resistance in Pancreatic Cancer

    The coinjection of pericyte stem cells and tumor epithelial cells led to increased tumor growth, differentiation of Ly6G+ myeloid-derived suppressor cells, and a decreased amount of F4/80+ macrophages and CD11c+ dendritic cells.
    [EMBO Reports]

    Full ArticleGraphical Abstract
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Functional States of Myeloid Cells in Cancer

    Scientists discuss recent data and concepts suggesting that the biology of myeloid cells is largely defined by a very limited number of functional states that transcend the narrowly defined cell populations.
    [Cancer Cell]

    Abstract

    State-of-the-Art Evidence in the Treatment of Systemic Sclerosis

    The authors review the evidence and efficacy of current treatments for systemic sclerosis, and highlight key areas where further research to better understand and treat the disease is necessary.
    [Nature Reviews Rheumatology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Kevzara® (Sarilumab) Approved by FDA As First and Only Biologic Indicated for Patients with Polymyalgia Rheumatica

    Regeneron Pharmaceuticals, Inc. and Sanofi announced that the US FDA has approved Kevzara® for the treatment of polymyalgia rheumatica, an inflammatory rheumatic disease, in adult patients who have had an inadequate response to corticosteroids or who cannot tolerate corticosteroid taper.
    [Regeneron Pharmaceuticals, Inc.]

    Press Release
    FEATURED EVENT

    Innate Immunity: From Innate Sensing to Adaptive Responses

    April 16 – 19, 2023
    Snowbird, Utah, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Intestinal Stem Cell Biology

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Professor – Experimental Immunology

    Karolinska Institutet – Solna, Sweden

    Research Officer – Bioinformatics

    The University of Melbourne – Melbourne, Australia

    Laboratory Technician – Flyak Lab

    Cornell University – Ithaca, New York, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immune Regulation News Twitter