 | | Vol. 15.09 – 10 March, 2023 |
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| Using unbiased metabolomics and stable isotope-assisted tracing, scientists showed that an inflammatory aspartate–argininosuccinate shunt was induced following lipopolysaccharide stimulation.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers compared the immunological milieux in the brain of mice with amyloid deposition or tau aggregation and neurodegeneration, to investigate the extent or role of the adaptive immune response and its interaction with the innate immune response in the presence of amyloid-β or tau pathology.
[Nature] |
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| To investigate the role of B cell receptor signaling in Germinal centers selection, the authors developed a tracker for antigen binding and presentation and a Bruton’s tyrosine kinase drug-resistant-mutant mouse model.
[Immunity] |
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| Mechanistically, intratissue Ruminococcus gnavus and Blautia producta degraded lyso-glycerophospholipids that inhibited CD8+ T cell activity and maintained the immune surveillance function of CD8+ T cells.
[Cell Host & Microbe] |
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| Mechanistically, immune checkpoint therapy induced lymph node remodeling and dendritic cell activation, which facilitated the translocation of a selective subset of gut bacteria to extraintestinal tissues to promote optimal antitumor T cell responses in both the tumor-draining lymph nodes and the primary tumor.
[Science Immunology] |
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| Scientists demonstrated that single low-dose immunizations with any of the three HPV-16 E7 oncoprotein and herpes simplex virus type 1 glycoprotein D (gDE7) mRNA vaccines induced activation of E7-specific CD8+ T cells and generated memory T cell responses capable of preventing tumor relapses.
[Science Translational Medicine] |
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| Investigators found that B cell receptor (BCR) ligation induced BCR signaling in IgE plasma cells (PCs) followed by their elimination. In cell culture, exposure of IgE PCs to cognate antigen or anti-BCR antibodies induced apoptosis.
[Journal Of Experimental Medicine] |
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| scRNA-seq and flow cytometry studies of different layers of intestinal cells revealed new cell subsets and modeled developmental trajectories of intestinal intraepithelial lymphocytes, lamina propria lymphocytes, conventional dendritic cells, and enterocytes.
[Journal of Experimental Medicine] |
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| The authors established a genetically engineered mouse model of BrafV600E-driven melanoma minimal residual disease, wherein genetic BrafV600E extinction led to strong but incomplete tumor regression.
[Cancer Immunology Research] |
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| Researchers identified a glycolytic intermediate metabolite, phosphoenolpyruvate, as a negative regulator of Th17 differentiation.
[Cell Reports] |
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| CD8+ T cell direct recognition of MHC class I, perforin/granzyme-mediated cytotoxicity, and extrinsic death receptor signaling such as Fas/FasL were all individually dispensable for equilibrium.
[Cell Reports] |
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| Chronological tracing of transcriptomic and epigenetic changes upon stimulation revealed that Dectin-2 induced early and strong signaling, whereas Mincle-mediated signaling was delayed, which reflected their expression patterns.
[Science Signaling] |
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| Oral immunotherapy for the treatment of food allergy incompletely targets subsets of type 2 immunity in a transient manner, but new therapeutics targeting different levels of type 2 immunity are in current or planned trials for food allergy.
[Journal Of Experimental Medicine] |
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| Biocytogen Pharmaceuticals (Beijing) Co., Ltd. announced the signing of a non-exclusive license agreement with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Jonson & Johnson.
[Biocytogen Pharmaceuticals (Beijing) Co., Ltd] |
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| April 23 – 26, 2023
Snowbird, Utah, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University Hospital Duesseldorf – Düsseldorf, Germany |
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| | Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Cornell University – Ithaca, New York, United States |
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