Immune Regulation News Volume 15.10 | Mar 17 2023

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    Laurisa Dohm
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    2023-03-17 | IRN 15.10


    Immune Regulation News by STEMCELL Technologies
    Vol. 4.30 – 17 March, 2023
    TOP STORY

    The Dietary Sweetener Sucralose Is a Negative Modulator of T Cell-Mediated Responses

    The authors showed that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation.
    [Nature]

    Full ArticlePress Release
    PUBLICATIONSRanked by the impact factor of the journal

    Cysteine Carboxyethylation Generates Neoantigens to Induce HLA-Restricted Autoimmunity

    Scientists found that that a cysteine residue of integrin αIIb was carboxyethylated in a process that required the gut microbe metabolite 3-hydroxypropionic acid and resulted in pathogenic neoantigens.
    [Science]

    Full ArticleGraphical Abstract

    Endoplasmic Reticulum Stress in the Intestinal Epithelium Initiates Purine Metabolite Synthesis and Promotes Th17 Cell Differentiation in the Gut

    Researchers found that Th17 cell-inducing gut bacteria generated an unfolded protein response (UPR) in intestinal epithelial cells (IECs). Subtilase cytotoxin expression or genetic removal of X-box binding protein 1 in IECs caused a UPR and increased Th17 cells, even in antibiotic-treated or germ-free conditions.
    [Immunity]

    AbstractGraphical AbstractPress Release

    p38MAPKa Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy

    The authors showed that p38MAPKa inhibition limited tumor growth by reprograming the metastatic tumor microenvironment in a CD4+ T cell, IFNy, and macrophage dependent manner.
    [Cancer Discovery]

    Full ArticlePress Release

    An XBP1s–PIM-2 Positive Feedback Loop Controls IL-15–Mediated Survival of Natural Killer Cells

    By using spliced X-box–binding protein 1 (XBP1s) conditional knockout mice, scientists found that XBP1s was critical for IL-15–mediated natural killer cell survival, but not proliferation, in vitro and in vivo.
    [Science Immunology]

    Full ArticlePress Release

    N-Acetylneuraminic Acid Links Immune Exhaustion and Accelerated Memory Deficit in Diet-Induced Obese Alzheimer’s Disease Mouse Model

    In an obese Alzheimer’s disease mouse model, hippocampal cells displayed only minor diet-related transcriptional changes, whereas the splenic immune landscape exhibited aging-like CD4+ T cell deregulation.
    [Nature Communications]

    Full Article

    FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-Cell Exhaustion in a Sex-Dependent Manner

    Single-cell RNA-sequencing and protein analyses uncovered a subpopulation of myeloid cells in pancreatic lesions associated with an immune‐excluded tumor phenotype and effector T-cell exhaustion exclusively in females.
    [Cancer Research]

    Full Article

    Species-Specific CD4+ T Cells Enable Prediction of Mucosal Immune Phenotypes From Microbiota Composition

    Using an adoptive transfer model of colitis, the authors found that lamina propria T cells responded to different bacterial strains in conditions of inflammation versus homeostasis.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    A Monoclonal Trd Chain Supports the Development of the Complete Set of Functional γδ T Cell Lineages

    To better understand the role of the γδ T cell receptor (TCR), investigators generated an orthotopic TCRδ transgenic mouse model. They demonstrated a multi-layered functionality of γδ TCRs and diverse roles of CDR3δ-mediated selection during γδ T cell development.
    [Cell Reports]

    Full ArticleGraphical Abstract

    DNA Demethylation Fine-Tunes IL-2 Production during Thymic Regulatory T Cell Differentiation

    Researchers showed that Tet3 selectively controlled the development of CD25− FoxP3lo CD4SP Treg cell precursors in the thymus, and was critical for TCR-dependent IL-2 production.
    [Embo Reports]

    Full ArticleGraphical Abstract
    Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.
    REVIEWS

    Tissue-Specific Macrophages: How They Develop and Choreograph Tissue Biology

    Scientists summarize our growing knowledge of macrophage diversity, how macrophage subsets orchestrate tissue development and function, and further interrelate macrophage ontogeny with their core functions across tissues.
    [Nature Reviews Immunology]

    Abstract

    Genetics and Epigenetics of Primary Sjögren Syndrome: Implications for Future Therapies

    The authors discuss the genetic and epigenetic features that have been robustly connected with primary Sjögren syndrome, putting them into the context of cellular function, carrier sex, and environmental challenges.
    [Nature Reviews Rheumatology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Suffering in Silence: Caring for Research Animals Can Take a Severe Mental toll. Is Anyone Listening?

    Everyone Science spoke to for this story who works with lab animals stressed that they are critical for biomedical research. These caregivers also feel deeply bonded to these creatures, from rodents to rabbits to monkeys. This dichotomy puts them in a difficult position.
    [Science]

    Press Release
    FEATURED EVENT

    Inflammation in the Lung: Friend or Foe in Viral Infections?

    April 23 – 26, 2023
    Snowbird, Utah, United States

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    JOB OPPORTUNITIES

    Assistant/Associate Professor – Immunity and Inflammation

    Rutgers New Jersey Medical School – Newark, New Jersey, United States

    Postdoctoral Position – Immunology of Infection and Vaccination

    Umeå University – Umeå, Sweden

    Postdoctoral Fellow – Translational Cancer Immunology and Biology

    University of Missouri – Columbia, Missouri, United States

    Senior Scientist – Preclinical Immunotherapy of Cancer

    University Hospital Duesseldorf – Düsseldorf, Germany

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    > See All Jobs

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