 | | Vol. 15.11 – 24 March, 2023 |
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| Scientists studied immunoglobulin G (IgG)-dependent initiation of resolution of inflammation in cytokine- and autoantibody-driven models of rheumatoid arthritis and found pooled serum IgG sialylation inhibited joint inflammation, whereas inhibition of osteoclastogenesis was sialic acid independent.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that reduction in specific Lactobacillus species, which are involved in T cell differentiation to protect the host immune system, contributed to stress-induced social-avoidance behavior.
[Nature Immunology] |
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| Researchers reported that the immunoglobin E/mast cell-mediated drop in body temperature in mice associated with anaphylaxis required the body’s thermoregulatory neural circuit, which was activated when granule-borne chymase from mast cells was deposited on proximal TRPV1+ sensory neurons.
[Science Immunology] |
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| The fluorescence of the probes was activated only in the presence of both tumor and leukocyte biomarkers, which allowed for the imaging of populations of specific tumor-infiltrating leukocytes in mouse models of cancers, with sensitivities and specificities similar to those achieved via flow-cytometric analyses of biopsied tumor tissues.
[Nature Biomedical Engineering] |
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| CRISPR-mediated genomic deletions validated the repressive function of distinct silencers involved in the repression of non-T cell genes and genes regulated during T cell differentiation.
[Nucleic Acids Research] |
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| Using two tracking methods, the authors observed that both CD88hiCD26lomonocytes and CD88−CD26hi migratory type 1 and type 2 conventional dendritic cells captured inhaled antigens in the lung and migrated to lymph nodes.
[Journal of Experimental Medicine] |
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| Researchers found that, in effector CD8 T lymphocytes, RNA-binding protein CPEB4 constituted a new branch of the unfolded protein response (UPR) that allowed cells to adapt to sustained endoplasmic reticulum stress, yet remained decoupled from the terminal UPR.
[EMBO Journal] |
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| Investigators showed that a high dose of IFN-β activated an inflammatory gene expression program in contrast to IFN-λ3, a type III IFN, which elicits only the common antiviral gene program.
[Molecular Systems Biology] |
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| To further investigate the consequences of conditional Sin3A inactivation in more mature precursors and post-thymic T cells, scientists generated CD4-Cre and CD4-CreERT2 Sin3AF/F mice.
[EMBO Reports] |
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| Investigators uncovered a new mechanism of immune modulation operating during skeletal muscle regeneration that was disrupted in aged animals and relied on the regulation of macrophage function.
[Nature Aging] |
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| The authors argue that some of the key evolutionary novelties of adaptive immune systems of vertebrates are descendants of prokaryotic toxin–antitoxin systems, and discuss how the emergence of adaptive immunity gave rise to higher order genetic conflicts between genetic parasites and their vertebrate host.
[Trends In Immunology] |
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| Scientists review the current knowledge about NOD-like receptors (NLRs), including the ligands and conditions that stimulate the NLRs and the outcomes of NLR activation in cells and animals. The NLRs play key roles in diverse functions, ranging from transcription of MHC, molecules to initiation of inflammation.
[Frontiers In Immunology] |
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| Remedium Bio and Exothera S.A. reached an agreement for a collaboration to demonstrate the industrialization potential of Remedium’s AAV2-FGF18. Remedium’s lead candidate is the only disease modifying gene therapy based on the clinically proven regenerative mechanism of FGF18 for osteoarthritis.
[Exothera S.A.] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | Dana-Farber Cancer Institute and Harvard Medical School – Boston, Massachusetts, United States |
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| | Ume̴ University РUme̴, Sweden |
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| | Pfizer, Inc. – Any North American Pfizer Site |
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| | Rutgers New Jersey Medical School – Newark, New Jersey, United States |
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| | University Hospital Duesseldorf – Düsseldorf, Germany |
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