 | | Vol. 15.13 – 14 April, 2023 |
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| Scientists demonstrated that in mice a maternal low-fiber diet led to enhanced lower respiratory infection severity in infants, because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The peptide-major histocompatibility complex class II (pMHCII) monospecific immunoregulatory T-cell pools that arose in vivo in different genetic backgrounds in response to pMHCII-coated nanoparticles were invariably comprised of oligoclonal subpools of T follicular helper and T regulatory type 1 cells.
[Cellular & Molecular Immunology] |
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| Investigators discovered that HIF-1α inhibitor at translation level (HITT), was transactivated by E2F1 under interferon-γ stimulation, and showed that HITT expression enhanced T cell-mediated cytotoxicity both in vitro and in vivo in a programmed death ligand 1 (PD-L1) dependent manner.
[Journal Of Clinical Investigation] |
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| Researchers reported the editing of primary human islet cells to the hypoimmune HLA class I– and class II–negative and CD47-overexpressing phenotype, and their reaggregation into human HIP pseudoislets.
[Science Translational Medicine] |
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| The authors leveraged the biocompatibility and immune activation capacity of Salmonella strain VNP20009 to produce double-layered membrane vesicles for enhanced systemic safety and antitumor immunity.
[ACS Nano] |
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| Mechanistic studies combining RNA sequencing, in vivo functional studies, and co-culture experiments were used to understand how the disruption of the mucosal-associated invariant T (MAIT) cell-monocyte/macrophage interaction resulted in resolution of fibrosis.
[Nature Communications] |
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| Investigators used CRISPR/Cas9-based genome editing to generate a mouse model that was deficient of all monocyte chemoattractant proteins, and used this strain to effectively abolish monocyte infiltration in genetically engineered murine models of de novo glioblastoma and hepatocellular carcinoma.
[Nature Communications] |
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| Chronic allergy stably induced T cell immunoreceptor with immunoglobin G and ITIM domains (TIGIT)+group-2 innate lymphoid cells (ILC2s), which were highly activated, apoptotic, and were quickly removed from sites of chronic allergy.
[Journal Of Experimental Medicine] |
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| RNA sequencing was performed on bone marrow-derived mast cells from wildtype and FcγRIIb-deficient mice to identify genes activated following immunoglobulin E receptor crosslinking that were further modulated in the presence antigen-specific immunoglobin G (IgG) in an FcγRIIb-dependent fashion.
[Journal Of Allergy And Clinical Immunology] |
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| Investigators showed that Tregs were recruited into murine brains following prime-central nervous system boost, but displayed altered phenotypes following repeated Ag-challenge.
[iScience] |
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| The authors discuss recent discoveries, including attribution of central nervous system immune surveillance to tissue-resident microglia and acknowledging the existence of a complex brain-immune network that involves multiple peripheral immunological players.
[Science] |
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| Scientists review ongoing efforts to dissect cellular and molecular heterogeneity in systemic lupus erythematosus (SLE), and how they could facilitate the future development of stratified treatment recommendations and precision medicine, which is a considerable challenge for SLE.
[Nature Reviews Rheumatology] |
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| The authors review the complex function of adipose tissue macrophages in adipose tissue homeostasis and metabolic inflammation.
[Nature Immunology] |
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| SAB Biotherapeutics announced that the US FDA has granted Fast Track designation for SAB-176, an investigational therapeutic for Type A and Type B influenza illness in high-risk patients, including those who have anti-viral resistant strains.
[SAB Biotherapeutics] |
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| May 15 – 19, 2023
Whistler, British Columbia, Canada |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | Pfizer, Inc.- Cambridge, Massachusetts, United States |
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| | Hudson Institute of Medical Research – Melbourne, Australia |
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| | Dana-Farber Cancer Institute and Harvard Medical School – Boston, Massachusetts, United States |
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