 | | Vol. 15.14 – 21 April, 2023 |
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| The authors engineered S. epidermidis generated tumor-specific T cells that infiltrated and reduced the growth of localized and metastatic melanoma.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that chemotherapy induced neutrophil recruitment and neutrophil extracellular trap (NET) formation, which reduced therapy response in mouse models of breast cancer lung metastasis. Chemotherapy-treated cancer cells secreted interleukin-1β, which in turn triggered NET formation.
[Cancer Cell] |
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| Investigators used multiplexed imaging, quantitative spatial analysis, and machine learning to create high-definition maps of lung tumors from a Kras/Trp53-mutant mouse model and human resections. Networks of interacting lymphocytes emerged as a distinctive feature of the anti-cancer immune response.
[Cancer Cell] |
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| During autoimmune neuroinflammation, the dura mater was only minimally affected, and neuroinflammation-induced helper T cell recruitment, activation, and polarization were significantly less pronounced in the dura mater than in the central nervous system,
[Science Immunology] |
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| Researchers showed that similar to Themis−/− thymocytes, the primary molecular defect in GRB2-deficient thymocytes was increased catalytically active SHP1 and the developmental block in GRB2-deficient thymocytes was alleviated by deletion or inhibition of SHP1 and exacerbated by SHP1 overexpression.
[Journal Of Experimental Medicine] |
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| Scientists combined single-cell RNA sequencing and genetic lineage tracing technology, then provided exact single-cell atlases of normal and ischemic limb tissues in human and mouse, finding that bone marrow–derived macrophages with antigen-presenting function migrated to the ischemic site.
[Science Advances] |
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| Investigators developed BCA101, an anti-EGFR IgG1 monoclonal antibody linked to an extracellular domain of human TGF-βRII. The TGF-β “trap” fused to the light chain in BCA101 did not sterically interfere with its ability to bind EGFR, inhibit cell proliferation, or mediate antibody-dependent cellular cytotoxicity.
[Cancer Research] |
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| Researchers discovered a functional role for Hedgehog (Hh) signaling in promoting Treg differentiation and immunosuppressive activity, and when Hh activity was inhibited, Tregs adopted a Th17-like phenotype complemented by an enhanced inflammatory profile.
[Cancer Immunology Research] |
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| Scientists examined how altered eIF4E activity affected T cell function using mice lacking eIF4E-binding proteins (BP-/-), finding that BP-/- effector T cells showed elevated Th1 responses ex vivo and upon viral challenge with enhanced Th1 differentiation observed in vitro.
[iScience] |
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| The authors provide a summary of the biology of the interleukin (IL)-12 family cytokines IL-12 and IL-23, discuss the role of these cytokines in intestinal homeostasis and inflammation, and highlight IL-12- and IL-23-directed drug development for the treatment of Crohn’s disease and ulcerative colitis.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists propose that Graves’ disease and Hashimoto’s thyroiditis have the same fundamental origin: both diseases are the cost of a beneficial physiological process called autoimmune surveillance of hypersecreting mutants.
[Trends In Immunology] |
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| The authors summarize the effects of changes in the glycolysis level of CD4+ T cells on their activation, differentiation, proliferation, and survival, and emphasized that regulation of the glycolysis level of CD4+ T cells changes their inflammatory phenotypes and function.
[Trends In Endocrinology And Metabolism] |
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| The Metrodora Institute has opened the doors of its medical and research center in Salt Lake City, giving biopharma companies a new neuroimmune drug development and clinical trial partner in Utah.
[Fierce Biotech] |
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| More than 40 editors have resigned from two leading neuroscience journals in protest against what the editors say are excessively high article-processing charges set by the publisher. They say that the fees, which publishers use to cover publishing services and in some cases make money, are unethical.
[Nature News & Views] |
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| May 15 – 19, 2023
Vancouver, British Columbia, Canada |
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| | Karolinska Institutet – Solna, Sweden |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | Pfizer, Inc.- Cambridge, Massachusetts, United States |
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| | Hudson Institute of Medical Research – Melbourne, Australia |
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